More and more people will experience thermal stress in the future as the global temperature is increasing at an alarming rate and the risk for extreme weather events is growing. The increased exposure to extreme weather events poses a challenge for societies around the world. This literature review investigates the feasibility of making advanced human thermal models in connection with meteorological data publicly available for more versatile practices and a wider population. By providing society and individuals with personalized heat and cold stress warnings, coping advice and educational purposes, the risks of thermal stress can effectively be reduced. One interesting approach is to use weather station data as input for the wet bulb globe temperature heat stress index, human heat balance models, and wind chill index to assess heat and cold stress. This review explores the advantages and challenges of this approach for the ongoing EU project ClimApp where more advanced models may provide society with warnings on an individual basis for different thermal environments such as tropical heat or polar cold. The biggest challenges identified are properly assessing mean radiant temperature, microclimate weather data availability, integration and continuity of different thermal models, and further model validation for vulnerable groups.
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http://dx.doi.org/10.3390/ijerph16224586 | DOI Listing |
Nat Struct Mol Biol
January 2025
Department of Biochemistry, Duke University School of Medicine, Durham, NC, USA.
Transient receptor potential channel subfamily M member 3 (TRPM3) is a Ca-permeable cation channel activated by the neurosteroid pregnenolone sulfate (PregS) or heat, serving as a nociceptor in the peripheral sensory system. Recent discoveries of autosomal dominant neurodevelopmental disorders caused by gain-of-function mutations in TRPM3 highlight its role in the central nervous system. Notably, the TRPM3 inhibitor primidone, an anticonvulsant, has proven effective in treating patients with TRPM3-linked neurological disorders and in mouse models of thermal nociception.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Materials Technologies, Faculty of Materials Engineering, Silesian University of Technology, 44-100, Gliwice, Poland.
eNeuro
January 2025
Department of Biomedical Sciences, University of Guelph
Chronic pain is a debilitative disease affecting 1 in 5 adults globally, and is a major risk factor for anxiety (Goldberg and McGee, 2011; Lurie, DI., 2018). Given the current dearth of available treatments for both individuals living with chronic pain and mental illnesses, there is a critical need for research into the molecular mechanisms involved in order to discover novel treatment targets.
View Article and Find Full Text PDFWaste Manag
January 2025
School of Environmental Science and Engineering, Zhejiang Provincial Key Laboratory of Solid Waste Treatment and Recycling, Zhejiang Engineering Research Center of Non-ferrous Metal Waste Recycling, Zhejiang Gongshang University, Hangzhou 310012, China. Electronic address:
Decentralized thermal treatment is a common method for municipal solid waste (MSW) disposal in rural areas. However, evaluating the effect of incineration has always been challenging owing to the difficult and time-consuming measurements involved. Herein, this study presented a rapid image recognition method for assessing the effects of thermal treatment on MSW using a neural network algorithm and a BAEVA 1.
View Article and Find Full Text PDFJ Clin Gastroenterol
January 2025
Department of Gastroenterology and Hepatology Creighton University, Omaha, NE.
Introduction: Thermal ablative methods (such as argon plasma coagulation (APC) and soft tip snare coagulation (STSC) are commonly used to treat polyp margins. We aim to appraise the current literature and compare clinical outcomes between patients with treated (with APC vs. STSC) and non-treated endoscopic mucosal resection (EMR) margins.
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