AI Article Synopsis
- China is a major country affected by multidrug-resistant tuberculosis (MDR-TB), and a nationwide study from 2009 to 2015 analyzed 1154 cases to understand drug resistance patterns and clinical features.
- Key predictors of MDR-TB in patients included cavitary disease, younger age, and a long history of tuberculosis, with higher resistance rates observed in major cities like Beijing, Shanghai, and Tianjin.
- Resistance to both first- and second-line anti-TB drugs was widespread, particularly among earlier cases and outpatients, highlighting the need for timely drug susceptibility testing and effective management strategies for better treatment outcomes.
Article Abstract
As China is one of high MDR-TB burden countries, it is important to determine the drug resistant pattern and clinical characteristics of multidrug resistant tuberculosis (MDR-TB). We conducted a comprehensive and nationwide study on MDR-TB in 17 provinces for the period from June 2009 to June 2015, and a total of 1154 cases of MDR-TB were finally investigated. The study sought to assess the clinical features and contrast drug susceptibility profiles of MDR-TB patients in China. Cavitary disease, young age, and long duration of TB disease among MDR-TB patients were important predictors. A high resistance proportion of first-line drugs was observed in Beijing, Shanghai and Tianjin. Resistant proportions of second-line anti-TB drugs in western region for amikacin, aminosalicylic acid, and levofloxacin were higher than eastern and central regions. High levels of drug resistance were seen in earlier cases (before 2011) and outpatients. We found high levels of resistance to 1st- and 2nd-line drugs in all settings, with considerable variabilities in terms of different Directly Observed Treatment Short Course (DOTS) programme, level of economic development(eastern, central and western regions) and patient source (inpatients and outpatients). Timely drug susceptibility testing (DST) and effective management are necessary to ensure an early detection of MDR-TB and its proper treatment.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874064 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0225361 | PLOS |
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