AI Article Synopsis
- Oral microbiota might be linked to pancreatic cancer risk due to periodontal disease, which is connected to certain microbes; a study in Iran assessed this relationship.
- The research involved 273 pancreatic cancer patients and 285 control participants who provided saliva samples; DNA analysis using advanced sequencing techniques was performed to compare their oral microbiota.
- While no differences in overall microbial diversity were found, significant differences in specific microbial communities between cancer cases and controls were observed, suggesting further investigation is necessary to determine if these differences precede cancer development.
Article Abstract
Background: Oral microbiota may be related to pancreatic cancer risk because periodontal disease, a condition linked to multiple specific microbes, has been associated with increased risk of pancreatic cancer. We evaluated the association between oral microbiota and pancreatic cancer in Iran.
Methods: A total of 273 pancreatic adenocarcinoma cases and 285 controls recruited from tertiary hospitals and a specialty clinic in Tehran, Iran provided saliva samples and filled out a questionnaire regarding demographics and lifestyle characteristics. DNA was extracted from saliva and the V4 region of the 16S rRNA gene was PCR amplified and sequenced on the MiSeq. The sequencing data were processed using the DADA2 plugin in QIIME 2 and taxonomy was assigned against the Human Oral Microbiome Database. Logistic regression and MiRKAT models were calculated with adjustment for potential confounders.
Results: No association was observed for alpha diversity with an average of 91.11 (standard deviation [SD] 2.59) sequence variants for cases and 89.42 (SD 2.58) for controls. However, there was evidence for an association between beta diversity and case status. The association between the Bray-Curtis dissimilarity and pancreatic cancer was particularly strong with a MiRKAT P-value of .000142 and specific principal coordinate vectors had strong associations with cancer risk. Several specific taxa were also associated with case status after adjustment for multiple comparisons.
Conclusion: The overall microbial community appeared to differ between pancreatic cancer cases and controls. Whether these reflect differences evident before development of pancreatic cancer will need to be evaluated in prospective studies.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970053 | PMC |
| http://dx.doi.org/10.1002/cam4.2660 | DOI Listing |
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