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Modular Synthesis of Planar-Chiral Cyclononenes via -Retentive Trapping of π-Allyl-Pd Dipoles.
J Am Chem Soc
January 2025
Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, P. R. China.
-cycloalkenes are abundant in bioactive natural products and have been used as powerful tools in chemical biology and drug discovery. However, strategies for the modular synthesis of -cycloalkenes, especially planar-chiral medium-sized ones, with high efficiency and selectivity, still remain elusive. Herein, we report a Pd-catalyzed asymmetric [7 + 2] cyclization strategy to address this challenge.
View Article and Find Full Text PDFA Protocol for Detecting DNA Methylation Changes at CpG Sites of Stemness-Related Genes in Aging Stem Cells.
Methods Mol Biol
January 2025
Department of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Aging adversely affects the self-renewal and differentiation capabilities of stem cells, which impairs tissue regeneration as well as the homeostasis. Epigenetic mechanisms, specifically DNA methylation, play a key role in the maintenance of pluripotency in stem cells and regulation of pluripotency-related gene expression. Age-related modifications in methylation patterns could influence the expression of genes critical for stem cell potency maintenance, including transcription factors Nanog and Sox2.
View Article and Find Full Text PDFPreparation of sulfur-doped porous carbon from polyphenylene sulfide waste for photothermal conversion materials to achieve solar-driven water evaporation.
Nanoscale
January 2025
College of Materials Science and Engineering, Hubei Provincial Engineering Research Center of Industrial Fiber Preparation and Application, Wuhan Textile University, Wuhan 430200, Hubei, China.
In recent years, solar-driven photothermal water evaporation technology for seawater desalination and wastewater treatment has developed rapidly, which is of great significance for addressing the issue of freshwater scarcity. However, due to the high costs associated with the manufacturing, maintenance, and operation of such devices, their application remains challenging in remote and resource-scarce regions. Due to its excellent light absorption capability in the near-infrared region, high hydrophilicity, and stable chemical properties, coupled with the low cost of recycling waste carbonized polyphenylene sulfide, this material is an excellent choice as a photothermal material for solar-driven water evaporation devices.
View Article and Find Full Text PDFCancer cells within tumors exhibit a wide range of phenotypic states driven by non-genetic mechanisms in addition to extensively studied genetic alterations. Conversions among cancer cell states can result in intratumoral heterogeneity which contributes to metastasis and development of drug resistance. However, mechanisms underlying the initiation and/or maintenance of such phenotypic plasticity are poorly understood.
View Article and Find Full Text PDFParallel layered scheme-based integrated orbit-attitude-vibration coupled dynamics and control for large-scale spacecraft.
ISA Trans
December 2024
National Key Laboratory of Aerospace Flight Dynamics, School of Astronautics, Northwestern Polytechnical University, Xi'an 710072, China; Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057, China. Electronic address:
This paper investigates an integrated model-control scheme for large-scale spacecraft, focusing on orbit-attitude-vibration dynamics subject to strong time-varying coupling characteristics. The proposed scheme aims to achieve cooperative modeling and control for orbit maintenance, attitude stabilization and vibration suppression simultaneously. An integrated dynamic model is established using the Absolute Nodal Coordinate Formulation and Lagrangian mechanics, where time-varying coupling terms are preserved to enhance model integrity, contrasting with the reduction and decoupling methods commonly adopted in existing literature.
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