Information on auto-brewery syndrome is limited in the medical literature. This rare syndrome occurs when yeast overgrowth leads to ethanol fermentation in the gut. We present a patient presenting with symptoms of alcohol intoxication with objective laboratory data of elevated blood ethanol levels without a history of alcohol consumption. We reviewed the literature and have discussed the current diagnostic and therapeutic options.
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http://dx.doi.org/10.14309/crj.0000000000000208 | DOI Listing |
J Hepatol
December 2024
Microbiology Department, Ramón y Cajal Hospital and Institute Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain; CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain; Faculty of Health Sciences, Alfonso X El Sabio University (UAX), Villanueva de la Cañada, Spain. Electronic address:
NeuroSci
September 2024
Nova Institute for Health, Baltimore, MD 21231, USA;
Nat Rev Gastroenterol Hepatol
August 2024
Department of Medicine, University of California San Diego, La Jolla, CA, USA.
The gut microbiome exerts metabolic actions on distal tissues and organs outside the intestine, partly through microbial metabolites that diffuse into the circulation. The disruption of gut homeostasis results in changes to microbial metabolites, and more than half of the variance in the plasma metabolome can be explained by the gut microbiome. Ethanol is a major microbial metabolite that is produced in the intestine of nearly all individuals; however, elevated ethanol production is associated with pathological conditions such as metabolic dysfunction-associated steatotic liver disease and auto-brewery syndrome, in which the liver's capacity to metabolize ethanol is surpassed.
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