AI Article Synopsis
- The text discusses a new method for coupling N-hydroxyphthalimide (NHP) esters with quinoxalinones using an electrochemical process aided by NiCl catalyst.
- This technique can effectively handle various types of carboxylic acids and amino acid-derived esters.
- The result of this decarboxylative coupling yields diverse 3-alkylated quinoxalinones with high efficiency, reaching up to 91% yield.
Article Abstract
Herein the first example of electrochemically enabled, NiCl-catalyzed reductive decarboxylative coupling of N-hydroxyphthalimide (NHP) esters with quinoxalinones is reported. A range of primary, secondary, tertiary aliphatic carboxylic acids and amino acid-derived esters were tolerated well. This decarboxylative coupling allows access to structurally diverse 3-alkylated quinoxalinones in up to 91% yields.
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| http://dx.doi.org/10.1039/c9cc07840a | DOI Listing |
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