AI Article Synopsis
- Tryptophan, an important amino acid, has potential implications in the study of gastric cancer metabolomics, but the role of its enantiomer, d-tryptophan, remains unclear.
- Researchers created four innovative sensors using various graphene materials and chemical modifiers to analyze and differentiate between l-tryptophan and d-tryptophan in whole blood samples.
- The results showed that these sensors are highly sensitive and reliable, paving the way for possible early detection and diagnosis of gastric cancer by understanding the significance of d-tryptophan.
Article Abstract
Tryptophan is a key amino acid related to metabolomics in gastric cancer. To date, methods were developed only for the assay of l-tryptophan, the role of d-tryptophan being not yet established. Therefore, four stochastic sensors based on different graphene materials modified with β-cyclodextrins, 2,2-diphenyl-1-picrylhydrazyl, and protoporphyrin IX were designed and used for enantioanalysis of tryptophan in whole blood samples. High sensitivities, and reliabilities were recorded when the stochastic sensors were used for the enantioanalysis of tryptophan in whole blood samples. The paper opened a new chapter in early detection of gastric cancer, based on establishing the role of d-tryptophan in metabolomics, and in early diagnosis of gastric cancer.
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| http://dx.doi.org/10.1002/chir.23155 | DOI Listing |
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