Chemical Constituents from the Aerial Parts of and Their Inhibitory Activities on Prostaglandin E Production in Lipopolysaccharide-Treated RAW 264.7 Macrophages.

A new flavone glucoside, acacetin-7--(3″--acetyl-6″--malonyl)-β-d-glucopyranoside (), two new phenolic glucosides, (3,7)-tuberonic acid-12--[6'--()-feruloyl]-β-d-glucopyranoside () and salicylic acid-2--[6'--()-feruloyl]-β-d-glucopyranoside (), and two new phenylpropanoid glucosides, chavicol-1--(6'--methylmalonyl)-β-d-glucopyranoside () and chavicol-1--(6'--acetyl)-β-d-glucopyranoside(), as well as 26 known compounds, -, , and -, were isolated from the aerial parts of . The structures of the new compounds were established by spectroscopic/spectrometric methods such as HRESIMS, NMR, and ECD. The anti-inflammatory effect of the isolated compounds was evaluated by measuring their inhibitory activities on prostaglandin E (PGE) in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. New compounds , , , and inhibited LPS-induced PGE production with IC values of 16.8 ± 0.8, 33.9 ± 4.8, 14.3 ± 2.1, and 48.8 ± 4.4 μM, respectively. Compounds , , -, , , , , and - showed potent inhibitory activities with IC values of 1.7-8.4 μM.