AI Article Synopsis
Article Abstract
A yolk-shell structured Au@Ag@mSiO2 probe was fabricated by coating a layer of mesoporous silica on the surface of a Au@Ag core-shell nanosphere, followed by partially removing the Ag shell. Mirror symmetrical chiral signals at ∼258 nm in the UV region were observed for the probe upon coupling with cysteine enantiomers on the surface of Au@Ag. The intensity of the CD signal of the probe is enhanced by increasing l/d-Cys concentration, allowing the quantitative determination of the cysteine enantiomers. The developed method shows an excellent linear relationship between the CD signal and l-Cys concentration ranging from 10 μM to 90 μM with a limit of detection of 8.5 μM. In the presence of Cu2+, the CD signal of the probe weakened due to the oxidation of l-cysteine to l-cystine catalyzed by Cu2+. Based on this phenomenon, a new strategy for the detection of Cu2+ can be developed. Under the optimized conditions, the CD signal decreases linearly with the log of the concentration of Cu2+ in the range from 1 to 250 nM with a detection limit of 0.1 nM.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c9an01541h | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Simultaneous separation and detection of common chiral and achiral metabolites in the urine of human exposed to benzene series by LC-MS/MS.
J Chromatogr B Analyt Technol Biomed Life Sci
January 2025
School of Ecology and Environment, Yuzhang Normal University, No.1999, Meiling Ave., Honggutan Dist., Nanchang 330103, Jiangxi, China.
Benzene, toluene, and xylene (BTX) are priority pollutants known for their hematotoxicity and carcinogenic properties. Benzene is further metabolized to phenyl mercapturic acid (PMA), toluene and xylene also generate benzyl mercapturic acid (BMA) in human urine. To confirm whether the exposure to benzene series comes from the workplace or from the external environment such as smoking is a very meaningful work, so accurate measurement of their biomarkers in biological samples is crucial.
View Article and Find Full Text PDFDual emission chiral carbon dots as fluorescent probe for fast chiral recognition of tryptophan enantiomers.
Anal Chim Acta
January 2025
National Engineering Laboratory/Key Laboratory of Henan Province, Henan University of Technology, Zhengzhou, 450001, China. Electronic address:
Article Synopsis
- Chirality is a critical aspect in various fields, including life sciences and pharmaceuticals, and chiral carbon dots (CCDs) show promise for chiral sensing, although suitable CCDs for tryptophan (Trp) enantiomers are limited.
- Researchers synthesized novel CCDs using l-lysine and l-cysteine, achieving unique chiral recognition that allows them to distinguish between L-Trp and D-Trp both by fluorescence intensity and emission wavelength, with a notable enantioselectivity ratio of 4.5 at 1 mM concentration.
- This study highlights a new chiral sensing platform with the potential for quantitative analysis and determining enantiomeric excess, paving the way for future advancements in
Chiral Cobalt Nanocluster-Driven Chemiluminescent System for the Facile Discrimination of Carnitine Enantiomers with a Hydrogel-Assisted Strategy.
Anal Chem
December 2024
Key Laboratory of Luminescence Analysis and Molecular Sensing (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Facile chiral discrimination without relying on chromatographic techniques has long been a huge challenge due to the minimal differences in the physicochemical properties of enantiomers. Polysaccharide hydrogels with natural chiral selectivity can be promising materials for constructing chiral discrimination platforms. In this study, l-cysteine-induced cobalt nanoclusters (LC-CoNCs) were prepared and utilized as chiral nanozymes for promoting the chemiluminescent (CL) signal of a luminol-HO system.
View Article and Find Full Text PDFFluorescence sensor array for highly sensitive pattern recognition of biothiols in food based on tricolor upconversion luminescence metal-organic frameworks.
J Nanobiotechnology
November 2024
College of Pharmaceutical Sciences, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University, Baoding, 071002, China.
Fluorescence nanomaterial sensors have exhibited excellent application potential in biothiols analyses. The fluorescence sensor arrays constructed from upconversion luminescence metal-organic frameworks nanocomposites (LMOFs) can provide impressive discrimination and exquisite fingerprinting capabilities for extremely similar analytes. Herein, an upconversion fluorescence sensor array based on LMOFs featuring UiO-type metal-organic frameworks-functionalized lanthanide-doped upconversion nanoparticles was proposed, wherein Cu can make the fluorescence quenching of LMOFs and preferentially bind biothiols to recover fluorescence in different degrees forming unique fingerprinting.
View Article and Find Full Text PDFProportionally controlled dual-chiral covalent organic frameworks via thiol-ene click reaction for efficient enantioseparation.
Talanta
February 2025
Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, 210009, China; Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, Nanjing, 210009, China. Electronic address:
Developing a universally applicable and commercially hopeful chiral material is a significant challenge for the separation and analysis field. In this study, innovative dual-chiral CCOFs ([SH-β-CD-NALC]-COFs) modified with 6-deoxy-6-mercapto-β-cyclodextrin (SH-β-CD) and N-acetyl-l-cysteine (NALC) are presented. These CCOFs were synthesized using a single, one-step bottom-up approach at room temperature, specifically designed for enantiomer recognition and separation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!