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Unlabelled: Age and sex have been found to be important determinants of the mutation rate per generation in mammals, but the mechanisms underlying these factors are still unclear. One approach to distinguishing between alternative mechanisms is to study species that reproduce at very young ages, as competing hypotheses make different predictions about patterns of mutation in these organisms. Here, we study the germline mutation rate in the gray short-tailed opossum, Monodelphis domestica, a laboratory model species that becomes reproductively mature at less than six months of age.
View Article and Find Full Text PDFRethinking Biomedical Titanium Alloy Design: A Review of Challenges from Biological and Manufacturing Perspectives.
Adv Healthc Mater
December 2024
School of Chemical Engineering, University of Birmingham, Birmingham, B15 2TT, UK.
Current biomedical titanium alloys have been repurposed from other industries, which has contributed to several biologically driven implant failure mechanisms. This review highlights the added value that may be gained by building an appreciation of implant biological responses at the onset of alloy design. Specifically, the fundamental mechanisms associated with immune response, angiogenesis, osseointegration and the potential threat of infection are discussed, including how elemental selection can modulate these pivotal systems.
View Article and Find Full Text PDFThe Antagonism Hypothesis: A New View on the Emergence of Consciousness.
Brain Behav
December 2024
School of Educational Science, Chongqing Normal University, Chongqing, China.
Purpose: The generation of consciousness poses a complex scientific challenge. Neuroscience and biological sciences have extensively studied this phenomenon, yielding numerous theories and hypotheses. However, to date, no reliable evidence has emerged to exclude any hypothesis conclusively, nor has any theory garnered unanimous agreement.
View Article and Find Full Text PDFPaneth Cells: Dispensable yet Irreplaceable for the Intestinal Stem Cell Niche.
Cell Mol Gastroenterol Hepatol
December 2024
Departments of Molecular & Integrative Physiology; Internal Medicine, University of Michigan, Ann Arbor, MI. Electronic address:
Intestinal stem cells replenish the epithelium throughout life by continuously generating intestinal epithelial cell types, including absorptive enterocytes, and secretory goblet, endocrine, and Paneth cells. This process is orchestrated by a symphony of niche factors required to maintain intestinal stem cells and to direct their proliferation and differentiation. Among the various mature intestinal epithelial cell types, Paneth cells are unique in their location in the stem cell zone, directly adjacent to intestinal stem cells.
View Article and Find Full Text PDFPerspectives on managing innovation readiness in long-term care: a Q-methodology study.
BMC Geriatr
December 2024
Department of Health Services Research, Faculty of Health, Medicine and Life Sciences, CAPHRI Care and Public Health Research Institute, Maastricht University, Duboisdomein 30, Maastricht, 6229 GT, The Netherlands.
Background: The scarcity of resources in long-term care demands more than ever that organizations in this sector are prepared for innovation to ensure affordable access to care for older adults. Organizations that are innovation ready are more capable of implementing innovations. Therefore, a better understanding of how stakeholders view innovation readiness in long-term care can provide actionable strategies to enhance their innovative capacities.
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