Vagal paragangliomas are rare tumors. Advances in the imaging have aided the diagnosis and assessment of this disease. Surgery is the mainstay of the treatment however radiotherapy has been tried in the selected cases. Surgery is associated with some mortality but with a lot of morbidity in view of cranial nerve deficit. The necessity to prevent additional cranial nerve deficits needs thorough preoperative evaluation and influences the therapeutic approach. This study involves the retrograde evaluation of five patients of vagal paraganglioma histopathologically confirmed, all the patients were operated via trancervical approach. Preoperatively three of five had 9, 11 and 12th cranial nerve involvement, one had horner's syndrome. Postoperative vocal rehabilitation was done in all the patient by medialisation thyroplasty Issiki type 1. Though vagal paragangliomas are associated with mortality and morbidity. Surgical treatment should aim at reducing mortality. Vagal nerve morbidity can be taken care as a planned and staged procedure mainly involving restoring voice as rest of concerns are taken care by compensation from opposite nerves.
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http://dx.doi.org/10.1007/s12070-018-1340-5 | DOI Listing |
Int J Surg Case Rep
December 2024
Université Mohammed V de Rabat, Avenue des Nations Unies, Agdal, Rabat Maroc, B.P:8007. N.U., Morocco; Department of Vascular Surgery, Centre Hospitalier Universitaire IBN SINA, Avenue Bettouga, Rabat 10000, Morocco.
Introduction And Importance: Cervical paragangliomas of the vagus nerve are tumors, of wich the nature and location make them extremely rare, representing only 0.012 % of cervical tumors.
Case Presentation: This article reports the case of a 64 year old patient, consulting for a latero-cervical mass associated with dysphonia, dysphagia, and repeated vagal syncopes, evolving for 10 months.
J Endocrinol Invest
December 2024
Nuclear Medicine and Molecular Imaging, ICANS, Strasbourg University Hospitals, Strasbourg University, Strasbourg, France.
Purpose: To investigate the influence of germline succinate dehydrogenase (SDHx) pathogenic variants on 6-[F]-fluoro-3,4-dihydroxyphenylalanine (F-DOPA) Positron Emission Tomography (PET) radiomic signature of head and neck paragangliomas (HNPGLs).
Methods: Forty-seven patients (20 SDH pathogenic variants carriers) harboring 55 HNPGLs were retrospectively included. HNPGLs were delineated using Nestle adaptive threshold.
Otolaryngol Head Neck Surg
January 2025
Endocrinology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.
Ann Otol Rhinol Laryngol
December 2024
Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Best Pract Res Clin Endocrinol Metab
December 2024
Department of Otology and Skull Base Surgery, Gruppo Otologico, 29121 Piacenza, Italy.
Head and neck paragangliomas (HNPGLs), rare neuroendocrine tumors that mainly arise from parasympathetic ganglia along the cranial nerves, are challenging due to anatomic origin, tendency to aggressive neurovascular and skull base infiltration, unpredictable metastatic potential, radio-chemoresistance, and risk of multiplicity. Symptoms range from mild to life threatening depending on location/size, but rarely relate to catecholamine excess. Risk factors include female sex and pathogenic germline variants in genes affecting hypoxia signaling (foremost succinate dehydrogenase genes).
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