Anti-Amyloidogenic and Cyclooxygenase Inhibitory Activity of .

Molecules

Department of Bionano Technology, Bionano Research Institute, Gachon University, 1342 Sungnam-daero, Sujung-gu, Seongnam-si, Gyeonggi-do 461-701, Korea.

Published: November 2019

is known in traditional folk medicine for treating cough, cold, sore throat, fever, wounds, epilepsy, and headaches. To discover the scientific pharmacological potential of , we explore its anti-inflammatory, cytotoxicity, and inhibition of amyloid- (Aβ) aggregation effects. Cyclooxygenase assay of the CHCl (GSC) extract and MeOH (GSM) extract are more selective to COX-1 inhibition with a 50% inhibitory concentration (IC) of 3.56 μg/mL for the GSC extract and 4.98 μg/mL for the GSM extract. Neuroblastoma SH-SY5Y inhibition and thioflavin T assay amyloid- (Aβ) aggregate inhibition of the GSM and GSC extracts showed their potential therapeutic effects against Alzheimer's disease. The putative compounds from the LC-MS analysis could be responsible for the observed activities. The results suggest that possesses anti-inflammatory and anti-neurodegenerative properties and a promising lead as a source of pharmacologically active compounds.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891569PMC
http://dx.doi.org/10.3390/molecules24224112DOI Listing

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