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Improved cortical boundary registration for locally distorted fMRI scans. | LitMetric

Improved cortical boundary registration for locally distorted fMRI scans.

PLoS One

Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.

Published: March 2020

AI Article Synopsis

  • Advances in MRI technology now allow for submillimetre spatial resolution in brain imaging, enabling more detailed studies, like exploring cortical layers.
  • With higher field strengths, geometrical distortions in echo planar imaging pose challenges for accurate analysis, leading to notable shifts that complicate laminar studies.
  • The proposed Recursive Boundary Registration (RBR) method effectively corrects these distortions by applying Boundary Based Registration iteratively, achieving high accuracy while maintaining cortical surface integrity, with the algorithm's code available on GitHub for public use.

Article Abstract

With continuing advances in MRI techniques and the emergence of higher static field strengths, submillimetre spatial resolution is now possible in human functional imaging experiments. This has opened up the way for more specific types of analysis, for example investigation of the cortical layers of the brain. With this increased specificity, it is important to correct for the geometrical distortions that are inherent to echo planar imaging (EPI). Inconveniently, higher field strength also increases these distortions. The resulting displacements can easily amount to several millimetres and as such pose a serious problem for laminar analysis. We here present a method, Recursive Boundary Registration (RBR), that corrects distortions between an anatomical and an EPI volume. By recursively applying Boundary Based Registration (BBR) on progressively smaller subregions of the brain we generate an accurate whole-brain registration, based on the grey-white matter contrast. Explicit care is taken that the deformation does not break the topology of the cortical surface, which is an important requirement for several of the most common subsequent steps in laminar analysis. We show that RBR obtains submillimetre accuracy with respect to a manually distorted gold standard, and apply it to a set of human in vivo scans to show a clear increase in spacial specificity. RBR further automates the process of non-linear distortion correction. This is an important step towards routine human laminar fMRI for large field of view acquisitions. We provide the code for the RBR algorithm, as well as a variety of functions to better investigate registration performance in a public GitHub repository, https://github.com/TimVanMourik/OpenFmriAnalysis, under the GPL 3.0 license.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6860425PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223440PLOS

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