Recent findings suggest that cognitive impairment can be associated with inflammation and immune changes in schizophrenia. We aimed to study possible associations between cytokine levels and cognitive performance in a sample of patients with schizophrenia. Cognition was assessed with the brief assessment of cognition in schizophrenia in 63 clinically stable outpatients with schizophrenia. Blood was collected and cytokines (IL-2, IL-4, IL-6, IL-10, IL-17A, TNF-α, IFN-γ) were measured by cytometric bead array method. Psychopathological scales were also applied. IL-6 correlated negatively with general cognitive performance (rho = -0.395, = .017) and positively with antipsychotic dose (rho = 0.412, = .004). Multiple regression analysis showed that cognitive performance is associated with age and antipsychotic dose ( = .000 and = .033). The association between IL-6 levels and cognitive performance is dependent on age and antipsychotic dose.
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| http://dx.doi.org/10.1080/08039488.2019.1688389 | DOI Listing |
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