AI Article Synopsis
- Congenital cytomegalovirus infection (CMVc) affects a notable percentage of newborns, leading to issues such as low birth weight and length.
- A study observed 383 children with CMVc, comparing their growth patterns in the first two years to World Health Organization standards, revealing that about 10% had significant growth impairments by 24 months.
- Factors such as being symptomatic at birth, being premature, and having motor or neurocognitive impairments increased the risk of these growth issues, suggesting that growth impairment should be recognized as part of CMVc's clinical profile.
Article Abstract
Background: Congenital cytomegalovirus infection (CMVc) affects 0.7%-6% of recent births. Among its clinical manifestations are low weight and length at birth.
Objective: Describe the growth patterns of children with CMVc in their early years.
Methods: Observational, multicenter study of patients with CMVc. Anthropometric data were collected during the first 2 years of life and compared with World Health Organization standards.
Results: Anthropometric characteristics of 383 children with CMVc were studied, of which 198 (51%) were symptomatic at birth. At birth, 9% were small for gestational age (SGA) in terms of their weight and length and 17% had microcephaly. At 24 ± 3 months, 10% had a weight and length ≤2 SD, and 13% a head circumference ≤2 SD. Of those who were SGA at birth, at 24 ± 3 months >20% remained at ≤2 SD of their weight and length. Conversely, 75% of children with low weight or length at 24 ± 3 had not been SGA at birth. 20% of infants with microcephaly at birth remained with microcephaly, and 10% of those without microcephaly developed it at 24 ± 3 months. The average growth rate in length and weight was normal. Patients who were symptomatic at birth, premature and with motor and neurocognitive impairment had a significantly higher risk of low weight and length at 24 ± 3 months.
Conclusion: Around 10% of children with CMVc are at ≤2 SD in weight, length and head circumference at 24 ± 3 months. The lack of adequate growth is associated with symptoms at birth, prematurity and motor and neurocognitive impairment. Growth impairment could be incorporated into the symptomatic spectrum of CMVc.
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| http://dx.doi.org/10.1097/INF.0000000000002483 | DOI Listing |
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