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Knee Buckling (Negative Myoclonus) Associated With Clozapine: Reports on 3 Cases. | LitMetric

AI Article Synopsis

Article Abstract

Background: Negative myoclonus is rarely seen in the clinical setting. It can be involved in some central nervous system pathologies. It has also been observed after antipsychotic treatment.

Case Reports: In this article, we will present 3 cases diagnosed with negative myoclonus in a 120-bed university-affiliated hospital within the past 7 years. Based on our clinical experience, it was observed that myoclonic jerk was a rare condition that started with suddenly dose changes. Patients showed good improvement in response to dose reduction.

Conclusions: Since the number of reported cases on negative myoclonus is limited, there is still a lack of well-established consensus on the management of this disease. It can be concluded that myoclonic jerk may be dose-dependent, sudden dose changes may be effective, anticonvulsants are not effective in all cases, and treatment can be achieved by reducing the dose.

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Source
http://dx.doi.org/10.1097/WNF.0000000000000370DOI Listing

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