Synthesis of Organometallic Oligonucleotides through Oximation with Metalated Benzaldehydes.

ACS Omega

Department of Chemistry, University of Turku, Vatselankatu 2, 20014 Turku, Finland.

Published: November 2019

A phthaloyl-protected aminooxymethyl--2'-deoxyriboside building block has been prepared and incorporated in the middle of an oligodeoxyribonucleotide. Removal of the phthaloyl protection followed by on-support oximation with either mercurated or palladated benzaldehydes yielded oligonucleotides bearing the respective benzaldoxime metallacycles.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854833PMC
http://dx.doi.org/10.1021/acsomega.9b02804DOI Listing

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