AI Article Synopsis
- L. is a medicinal plant found in Europe, North America, and Asia, traditionally used for treating various ailments and studied for its antioxidant and anti-inflammatory effects on human umbilical vein endothelial cells (HUVECs).
- The research highlights the extracts from the aerial parts and roots, showing how they influence the expression of crucial antioxidant and inflammation-related genes when cells are stimulated, while also exhibiting some antibacterial and antifungal properties.
- The root extract (MtRV) demonstrated more potent protective effects against DNA damage and better biological properties compared to the aerial part extract (MtAPV), potentially due to a higher concentration of beneficial compounds like phenolic acids and betulinic acid.
Article Abstract
L. is a valuable medical plant found in Europe, North America, and Asia, which grows on peat bogs and swamps. It has long been used in folk medicine as a remedy for various ailments. This is the first report to demonstrate the protective antioxidant and anti-inflammatory properties of aqueous methanolic extracts derived from the aerial parts (MtAPV) and roots (MtRV) of grown plants on human umbilical vein endothelial cells (HUVECs). It describes the influence of the tested extracts on the expression of antioxidant (HO-1, NQO1, , , and ) and inflammation-related genes (, , , , and ) in cells stimulated with HO or LPS, respectively. In addition, extracts were found to moderately affect the growth of certain bacterial and fungal pathogens, with the strongest antibacterial effect found against and . extracts demonstrated protective effects against mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) damage caused by ROS, decreasing the numbers of mtDNA lesions in the and genes and nDNA damage in the and genes and reducing cleavage in PARP1- and -H2A.X-positive cells. The root extract of (MtRV) appears to have better anti-inflammatory, antioxidant, antimicrobial, and protective properties than the extract from the aerial part (MtAPV). These differences in biological properties may result from the higher content of selected phenolic compounds and betulinic acid in the MtRV than in the MtAPV extract.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816005 | PMC |
| http://dx.doi.org/10.1155/2019/9165784 | DOI Listing |
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