The asymmetric hydrogenation of 2,4-pentadien-1-ones has been achieved by using -RuCl[()-XylylSunPhos][()-Daipen] as a catalyst under basic conditions. This hydrogenation demonstrated exclusive C1-carbonyl selectivity, and thus the conjugated 2,4-diene motifs remained untouched, which provides a synthetically useful method for various chiral 2,4-pentadien-1-ols.
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| http://dx.doi.org/10.1021/acs.joc.9b02576 | DOI Listing |
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