A 59-year-old man who was receiving lenvatinib as a third-line tyrosine kinase inhibitor to treat hepatocellular carcinoma and multiple bone metastases complained of general fatigue four months after starting lenvatinib. A blood examination showed unexpectedly elevated serum C-reactive protein (CRP) levels. Computed tomography (CT) revealed rupture of the gallbladder wall, indicating gallbladder perforation. After conservative treatment, the patient received lenvatinib again under informed consent; however, one month later, CT revealed repeated rupture of the gallbladder wall. Gallbladder perforation had again been induced by lenvatinib. For this reason, lenvatinib is strongly considered a causative drug for gallbladder perforation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086315 | PMC |
| http://dx.doi.org/10.2169/internalmedicine.3806-19 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
How do inflammatory marker dynamics shift with acute calculous cholecystitis severity?
Ulus Travma Acil Cerrahi Derg
January 2025
Department of General Surgery, Istanbul Training and Research Hospital, Istanbul-Türkiye.
Introduction: Gallstone may cause complications of cholecystitis, gallbladder gangrene, perforation, and related sepsis. This study aims to identify how CRP and immune cells change in patients with acute calculous cholecystitis based on the severity of disease.
Method: Patients with acute calculous cholecystitis were categorized into three main groups-mild, moderate, and severe-based on the Tokyo guidelines.
Gallbladder perforation causing local peritonitis in left upper abdomen: A case report.
Int J Surg Case Rep
January 2025
Department of Surgery, Osaka City Juso Hospital, Osaka, Japan.
Introduction And Importance: Type 1 gallbladder perforation (GBP) in the free abdominal cavity causes pan-peritonitis, which is both rare and difficult to diagnose.
Case Presentation: An 80-year-old man presented to our hospital with acute left upper abdominal pain. Twenty days prior to presentation, he had been admitted for 12 days with coronavirus disease 2019 (COVID-19).
Hemorrhagic cholecystitis afflicted with glanzmann thrombasthenia patient.
J Family Med Prim Care
November 2024
Department of Basic Science College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Article Synopsis
- Hemorrhagic cholecystitis is a rare but serious condition that can occur if the gallbladder bursts, necessitating urgent medical intervention.
- A 27-year-old man with Glanzmann's thrombasthenia visited the emergency department multiple times, initially presenting with ear and later chest pain, before being misdiagnosed and sent home.
- Upon returning with abdominal symptoms, an ultrasound confirmed cholecystitis, leading to an emergency surgery that uncovered the hemorrhagic cholecystitis diagnosis.
Improved detection of gallbladder perforation by contrast-enhanced ultrasound: two case reports.
Front Med (Lausanne)
December 2024
Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, China.
Acute cholecystitis is a common acute abdominal disease, but the occurrence of secondary gallbladder perforation is relatively rare, and poses a serious threat to the lives of patients. The conventional methods for diagnosing acute cholecystitis are abdominal contrast-enhanced CT and ultrasound. However, these methods may have limitations in detecting gallbladder perforation, especially in cases where perforation size are small.
View Article and Find Full Text PDFLaparoscopic Management of Spontaneous Gallbladder Perforation in Acalculous Cholecystitis: A Case Series.
Cureus
November 2024
General Surgery, Max Super Specialty Hospital, New Delhi, IND.
Gallbladder perforation in acalculous cholecystitis is rare and has a high mortality rate due to biliary peritonitis and sepsis. Here, we present a case series of successful laparoscopic management of Spontaneous gallbladder perforation in acalculous cholecystitis. In the first case, a 44-year-old male patient presented to the emergency room with a history of three days of fever with chills and acute pain in the abdomen for two days.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!