Dr. Michael K. Cahalan, former chair of the Department of Anesthesiology at the University of Utah School of Medicine, died March 9, 2019, at the age of 69 after a brief illness. He was a giant in anesthesiology and a pioneer in the development of transesophageal echocardiography applications in anesthesia. He made many other important contributions to the specialty of anesthesiology, having achieved a notable measure of success in all the traditional missions of academics, including research, teaching, clinical care, and administration. In this summary, his early life, education, and the contributions he made to the practice of anesthesiology in general and to cardiac anesthesia and echocardiography in particular are reviewed. The attributes that made Cahalan a model in the profession of anesthesiology that all can strive to emulate also are described.
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http://dx.doi.org/10.1053/j.jvca.2019.09.027 | DOI Listing |
PNAS Nexus
November 2024
Department of Biomedical Engineering, University of California, Irvine, Irvine 92697, USA.
Macrophages in the vascular wall ingest and clear lipids, but abundant lipid accumulation leads to foam cell formation and atherosclerosis, a pathological condition often characterized by tissue stiffening. While the role of biochemical stimuli in the modulation of macrophage function is well studied, the role of biophysical cues and the molecules involved in mechanosensation are less well understood. Here, we use genetic and pharmacological tools to show extracellular oxidized low-density lipoproteins (oxLDLs) stimulate Ca signaling through activation of the mechanically gated ion channel Piezo1.
View Article and Find Full Text PDFCommun Biol
August 2024
Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA.
Pain and inflammation contribute immeasurably to reduced quality of life, yet modern analgesic and anti-inflammatory therapeutics can cause dependence and side effects. Here, we screened 1444 plant extracts, prepared primarily from native species in California and the United States Virgin Islands, against two voltage-gated K channels - T-cell expressed Kv1.3 and nociceptive-neuron expressed Kv7.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2023
Department of Physiology and Biophysics, University of California, Irvine, CA 92697.
We used electrophysiology and Ca channel tethering to evaluate the performance of jGCaMP8 genetically encoded Ca indicators (GECIs). Orai1 Ca channel-jGCaMP8 fusions were transfected into HEK 293A cells and jGCaMP8 fluorescence responses recorded by simultaneous total internal reflection fluorescence microscopy and whole-cell patch clamp electrophysiology. Noninactivating currents from the Orai1 Y80E mutant provided a steady flux of Ca controlled on a millisecond time scale by step changes in membrane potential.
View Article and Find Full Text PDFNat Commun
March 2023
Department of Neurobiology & Behavior, University of California Irvine, Irvine, CA, 92697, USA.
Sci Signal
June 2022
Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697, USA.
Calcium (Ca) signaling has long been known to be crucial for T cell activation. Erdogmus . tested the function of voltage-gated Ca channel (CaV) proteins and discovered a nonchannel function mediated by an accessory subunit but found no evidence for CaV channel activity in T cells.
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