Michael K. Cahalan: In Celebration of His Life and Contributions to Cardiac Anesthesiology.

J Cardiothorac Vasc Anesth

Department of Anesthesiology, University of Utah, Salt Lake City, UT.

Published: January 2020

Dr. Michael K. Cahalan, former chair of the Department of Anesthesiology at the University of Utah School of Medicine, died March 9, 2019, at the age of 69 after a brief illness. He was a giant in anesthesiology and a pioneer in the development of transesophageal echocardiography applications in anesthesia. He made many other important contributions to the specialty of anesthesiology, having achieved a notable measure of success in all the traditional missions of academics, including research, teaching, clinical care, and administration. In this summary, his early life, education, and the contributions he made to the practice of anesthesiology in general and to cardiac anesthesia and echocardiography in particular are reviewed. The attributes that made Cahalan a model in the profession of anesthesiology that all can strive to emulate also are described.

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.jvca.2019.09.027DOI Listing

Publication Analysis

Top Keywords

michael cahalan
8
anesthesiology
6
cahalan celebration
4
celebration life
4
life contributions
4
contributions cardiac
4
cardiac anesthesiology
4
anesthesiology michael
4
cahalan chair
4
chair department
4

Similar Publications

Macrophages in the vascular wall ingest and clear lipids, but abundant lipid accumulation leads to foam cell formation and atherosclerosis, a pathological condition often characterized by tissue stiffening. While the role of biochemical stimuli in the modulation of macrophage function is well studied, the role of biophysical cues and the molecules involved in mechanosensation are less well understood. Here, we use genetic and pharmacological tools to show extracellular oxidized low-density lipoproteins (oxLDLs) stimulate Ca signaling through activation of the mechanically gated ion channel Piezo1.

View Article and Find Full Text PDF

Pain and inflammation contribute immeasurably to reduced quality of life, yet modern analgesic and anti-inflammatory therapeutics can cause dependence and side effects. Here, we screened 1444 plant extracts, prepared primarily from native species in California and the United States Virgin Islands, against two voltage-gated K channels - T-cell expressed Kv1.3 and nociceptive-neuron expressed Kv7.

View Article and Find Full Text PDF

We used electrophysiology and Ca channel tethering to evaluate the performance of jGCaMP8 genetically encoded Ca indicators (GECIs). Orai1 Ca channel-jGCaMP8 fusions were transfected into HEK 293A cells and jGCaMP8 fluorescence responses recorded by simultaneous total internal reflection fluorescence microscopy and whole-cell patch clamp electrophysiology. Noninactivating currents from the Orai1 Y80E mutant provided a steady flux of Ca controlled on a millisecond time scale by step changes in membrane potential.

View Article and Find Full Text PDF

Voltage-gated Ca channel proteins do not function as ion channels in T cells.

Sci Signal

June 2022

Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697, USA.

Calcium (Ca) signaling has long been known to be crucial for T cell activation. Erdogmus . tested the function of voltage-gated Ca channel (CaV) proteins and discovered a nonchannel function mediated by an accessory subunit but found no evidence for CaV channel activity in T cells.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!