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Background: The immerging role of CD8+T cells, interferon and the adaptive immune response in AD is consistent with previous observations of the putative role of neurotrophic herpesvirus family infections contributing to Alzheimer's Disease pathophysiology. An outstanding question is how chronic viral infections over decades may contribute to AD pathogenesis. Our HSV-1 reactivation model aims to provide insights to this question.
View Article and Find Full Text PDFInvasive group A streptococcal infections as a consequence of coexisting or previous viral infection in the post-COVID-19 pandemic period.
J Infect Public Health
January 2025
Department of Infectious Diseases and Child Neurology, Institute of Paediatrics, Poznan University of Medical Sciences, Poland.
Background: Group A Streptococci (GAS) may cause infections of the pharynx and soft tissues and invasive infections in children (iGAS). A significant increase in severe iGAS infections has been reported in Europe since the fall of 2022.
Objectives: This retrospective study aims to analyse clinical data of children with invasive and non-invasive GAS infections in the post-COVID-19 pandemic era, searching for predisposing factors to developing invasive infections.
Multiple primary brain abscesses in a 14 years old immunocompetent boy: A tale of Proteus mirabilis infestation from Pakistan.
Pak J Med Sci
December 2024
Muhammad Talha Bilal, Post Graduate Resident, Department of Neurosurgery, Unit-I, Punjab Institute of Neurosciences, Lahore, Pakistan.
Brain abscess (BA) formation that may be due to due to Gram-positive bacteria commonly and less commonly due Gram-negative bacteria affects pediatric population. Most cases are secondary to the involvement of ear, nose, throat and sinuses (ENTS). We describe a rare case of a 14 year old patient presenting with generalized tonic clonic seizures for the last six months associated with fever, vomiting and headache.
View Article and Find Full Text PDFAngioarchitecture and Endovascular Therapy of Infantile Dural Arteriovenous Fistulas.
Neurol India
November 2024
Department of Neurosurgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Infantile dural arteriovenous fistula (IDAVF) is a rare complex dural arteriovenous fistulas. This study is to provide a comprehensive understanding of the angioarchitecture of arteriovenous shunts in IDAVFs and planning endovascular treatment. Five cases of IDAVF and a literature review were analyzed to characterize the shunt patterns of IDAVFs in terms of anatomic relations to the arterial feeder, sinuses, and cortical veins.
View Article and Find Full Text PDFDeep Fungal Infections of Skin and Role of Histopathology in Diagnosis.
Indian J Dermatol
October 2024
Department of Dermatology, Institute of Child Health, Kolkata, India.
Introduction: Deep mycoses acquired by penetrating trauma to the skin can have varied and sometimes atypical morphological presentations resulting in diagnostic dilemmas and delay in treatment onset. Histopathology can be a useful tool in not only diagnosing but also differentiating various deep mycoses.
Aims And Objectives: To observe various morphological presentations and histopathological features of deep fungal infections.
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