AI Article Synopsis
- A study was conducted to investigate the relationship between kidney transplantation (KT) and the risk of colorectal cancer (CRC) in a large population of hemodialysis patients in Taiwan.
- The research involved comparing 3,739 patients who underwent KT with 42,324 patients who did not undergo KT from 2000 to 2008, using data from the National Health Insurance Research Database.
- Results indicated that patients who received KT had a significantly higher cumulative incidence of CRC compared to those who did not, suggesting a need for ongoing cancer prevention strategies in KT recipients.
Article Abstract
Background: Kidney transplantation (KT) correlates with an increased risk of developing several malignancies; however, the risk of colorectal cancer (CRC) after KT remains debatable and has been marginally explored. Hence, in this nationwide, retrospective, population-based cohort study, we aimed to examine the correlation between KT and CRC in a large-scale population-based Chinese cohort.
Methods: We identified a total of 3739 regular hemodialysis patients undergoing KT (exposed cohort) and 42,324 hemodialysis patients not undergoing KT (non-exposed cohort) between 2000 and 2008 from Taiwan's National Health Insurance Research Database (NHIRD). Both cohorts were followed up from January 1, 2000, to the date of CRC diagnosis, death, or the end of 2013. Using Kaplan-Meier method, we measured the cumulative incidence of CRC in each cohort. Furthermore, Cox proportional hazards models were used to compute hazards ratios (HRs) and 95% confidence intervals (CIs) to estimate the correlation between KT and CRC in hemodialysis patients.
Results: The Kaplan-Meier analysis revealed that the cumulative incidence of CRC was significantly higher in the exposed cohort than in the non-exposed cohort (log-rank test, P < 0.001). After adjusting for potential confounders, the exposed cohort exhibited a significantly increased risk of CRC compared with the non-exposed cohort (adjusted HR, 1.34; 95% CI, 1.11-1.62).
Conclusions: Hemodialysis patients undergoing KT have a significantly higher risk of CRC than those not undergoing KT. Cancer should continue to be a primary focus of prevention during KT.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858634 | PMC |
| http://dx.doi.org/10.1186/s12885-019-6283-z | DOI Listing |
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