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Dominant myosin storage myopathy mutations disrupt striated muscles in Drosophila and the myosin tail-tail interactome of human cardiac thick filaments.
Genetics
January 2025
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA.
Myosin storage myopathy (MSM) is a rare skeletal muscle disorder caused by mutations in the slow muscle/β-cardiac myosin heavy chain (MHC) gene. MSM missense mutations frequently disrupt the tail's stabilizing heptad repeat motif. Disease hallmarks include subsarcolemmal hyaline-like β-MHC aggregates, muscle weakness, and, occasionally, cardiomyopathy.
View Article and Find Full Text PDFProbing the interactions between asphaltenes and a PEO-PPO demulsifier at oil-water interface: Effect of temperature.
J Colloid Interface Sci
January 2025
Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 1H9, Canada. Electronic address:
Hypothesis: Asphaltenes are primary stabilizers in water-in-oil (W/O) emulsions that cause corrosion and fouling issues. In oil sands industry, oil/water separation processes are generally conducted at high temperatures. A high temperature is expected to impact the interactions between asphaltenes and emulsion breakers (EBs), consequently influencing demulsification performance.
View Article and Find Full Text PDFDetection and Characterization of Methylated Circulating Tumor DNA in Gastric Cancer.
Int J Mol Sci
July 2024
Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute, Jeonbuk National University Hospital, 634-18 Keuman-dong, Dukjin-gu, Jeonju-si 54907, Republic of Korea.
Article Synopsis
- - Gastric cancer ranks as the fifth most common cancer worldwide and is the fourth leading cause of cancer-related deaths; early detection remains challenging despite existing diagnostic methods like esophagogastroduodenoscopy with biopsy.
- - Recent research is focusing on liquid biopsy techniques to diagnose gastric cancer by analyzing specific cancer-derived substances found in blood, although these substances are present in very small quantities and vary significantly among individuals and cancer types.
- - The study collected and analyzed methylated DNA fragments from both cancer tissue and patient's plasma, revealing a 41.2% consistency rate in identifying common methylated fragments, suggesting potential for improved diagnosis and characterization of gastric cancer.
[Visualization of mitochondrial dynamics in tomato based on green fluorescent protein].
Sheng Wu Gong Cheng Xue Bao
April 2024
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
This study aimed to visualize the morphological features and dynamic changes of tomato mitochondria to provide a basis for the study of its mitochondrial functions. In this study, transgenic tomatoes expressing mitochondria-localized green fluorescent protein (mitochondria-GFP, Mt-GFP) were obtained by -mediated genetic transformation. The color, hardness, soluble solids, acidity content, respiration rate, and ethylene production of the transgenic Mt-GFP tomato fruits were determined at the stage of mature green, breaker, and 3, 6, 9 days after breaker, while the wild-type tomato fruits were used as a control.
View Article and Find Full Text PDFBetter to bend than to break? Effects of rule behavior on dominance, prestige, and leadership granting.
J Exp Psychol Appl
June 2024
Department of Social Psychology, University of Amsterdam.
Article Synopsis
- People are more inclined to favor leaders who follow the rules rather than those who break them, but the preference for rule followers isn't as strong as expected.
- The study introduces "rule-bending," which refers to actions that push the limits of a rule without outright breaking it, and finds that rule-benders are viewed as more prestigious and dominant, making them more attractive as leaders compared to outright rule-breakers.
- Rule-bending can be advantageous in competitive situations, as it allows individuals to showcase their dominance, leading to increased leadership appeal in those contexts.
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