AI Article Synopsis
- Chronic rhinosinusitis (CRS) and asthma can occur together due to inflammation, and biomarkers help in studying these conditions.* -
- The review covered important biomarkers for CRS, including nasal nitric oxide, pendrin, and periostin, while for asthma, it focused on fractional exhaled nitric oxide and other mediators in exhaled breath.* -
- Nasal nitric oxide is the most informative biomarker for CRS, while fractional exhaled nitric oxide is key for asthma; however, more research is necessary for other potential biomarkers.*
Article Abstract
Background: In the context of the so-called unified airway theory, chronic rhinosinusitis (CRS) and asthma may coexist. The inflammation underlying these conditions can be studied through the aid of biomarkers. Main body: We described the main biological mediators that have been studied in pediatric CRS and asthma, and, according to the available literature, we reported their potential role in the diagnosis and management of these conditions. As for CRS, we discussed the studies that investigated nasal nitric oxide (nNO), pendrin, and periostin. As for asthma, we discussed the role of fractional exhaled nitric oxide (feNO), the role of periostin, and that of biological mediators measured in exhaled breath condensate (EBC) and exhaled air (volatile organic compounds, VOCs).
Conclusion: Among non-invasive biomarkers, nNO seems the most informative in CRS and feNO in asthma. Other biological mediators seem promising, but further studies are needed before they can be applied in clinical practice.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912805 | PMC |
| http://dx.doi.org/10.3390/jcm8111783 | DOI Listing |
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