AI Article Synopsis
- Parkinson's disease involves the loss of specific brain cells (dopaminergic neurons) that are essential for movement.
- Researchers are exploring the possibility of replacing these lost neurons using cells derived from pluripotent stem cells, but scaling up the production has been challenging.
- The study found that using a controlled freezing method with specific medium (STEM-CELLBANKER) can effectively preserve immature human dopaminergic neurons, potentially making them easier to produce and store for future use.
Article Abstract
Parkinson's disease is associated with the loss of dopaminergic neurons in the midbrain. Clinical studies investigating replacement of these neurons with in vitro-generated neurons are currently underway. However, this approach has been limited by difficulties in scaling up on-demand production of midbrain dopaminergic (mDA) neurons from pluripotent stem cells. Cryo-preservation may offer a solution, as it allows for banking of quality controlled mDA neurons. In this study, we tested different freezing conditions and found that optimal cryopreservation of immature human mDA neurons at an early differentiation time point was achieved in STEM-CELLBANKER medium using a controlled freezing program.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.scr.2019.101617 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!