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Potential role of hypothalamic microRNAs in regulation of FOS and FTO expression in response to hypoglycemia. | LitMetric

Potential role of hypothalamic microRNAs in regulation of FOS and FTO expression in response to hypoglycemia.

J Physiol Sci

Family Medicine and Behavioral Science, College of Medicine, University of Sharjah, P.O. Box: 27272, Sharjah, United Arab Emirates.

Published: November 2019

AI Article Synopsis

  • - HAAF (Hypoglycemia-associated autonomic failure) is a serious diabetes complication linked to the failure of the hypothalamus and sympathetic nervous system to respond to low glucose levels.
  • - The study found that hypoglycemia significantly reduces the survival of hypothalamic neurons and increases their apoptotic rate in a dose-dependent manner.
  • - Among over 1000 different miRNAs in the hypothalamus, twelve specific miRNAs were identified that correlate with key proteins FOS and FTO, which are sensitive to hypoglycemia.

Article Abstract

Hypoglycemia-associated autonomic failure (HAAF) is a serious complication of diabetes which is associated with the absence of physiological homeostatic counter-regulatory mechanisms that are controlled by the hypothalamus and sympathetic nervous system. Identification of biomarkers for early detection of HAAF requires an advanced understanding of molecular signature of hypoglycemia which is yet to be identified. The outcomes of the present study have shown that the viability and the apoptotic rate of the hypothalamic neurons (mHypoE-N39) were decreased significantly due to hypoglycemia in a dose-dependent fashion (p < 0.05). Although there are more than 1000 miRNAs differentially expressed in hypothalamus, only twelve miRNAs (miR-7a, miR-7b, miR-9, miR-29b, miR-29c, miR-30a, miR-30b, miR-30c, miR-101b-3p, miR-181a-5p, miR-378-3p and miR-873-5p) were correlated to two main hypothalamic regulatory proteins, FOS and FTO. Expression of these proteins was very sensitive to hypoglycemia. We demonstrated that hypoglycemia modulates the expression of hypothalamic miRNAs that are related to FOS and FTO.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717546PMC
http://dx.doi.org/10.1007/s12576-019-00718-0DOI Listing

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