AI Article Synopsis
- - FGF21 is a protein produced mainly by the liver, influencing metabolic functions and found in tissues like fat and pancreas.
- - Researchers created a liver-specific knockout model to study the effects of FGF21 on metabolism during different diets, particularly a ketogenic diet (KD).
- - Results showed that mice lacking FGF21 in the liver had reduced energy expenditure and liver issues on a KD, indicating that FGF21 is crucial for adapting to ketosis but has a lesser role in managing blood sugar levels.
Article Abstract
Background: Fibroblast growth factor 21 (FGF21) is expressed in several metabolically active tissues, including liver, fat, and acinar pancreas, and has pleiotropic effects on metabolic homeostasis. The dominant source of FGF21 in the circulation is the liver.
Objective And Methods: To analyze the physiological functions of hepatic FGF21, we generated a hepatocyte-specific knockout model (LKO) by mating albumin-Cre mice with FGF21 flox/flox (fl/fl) mice and challenged it with different nutritional models.
Results: Mice fed a ketogenic diet typically show increased energy expenditure; this effect was attenuated in LKO mice. LKO on KD also developed hepatic pathology and altered hepatic lipid homeostasis. When evaluated using hyperinsulinemic-euglycemic clamps, glucose infusion rates, hepatic glucose production, and glucose uptake were similar between fl/fl and LKO DIO mice.
Conclusions: We conclude that liver-derived FGF21 is important for complete adaptation to ketosis but has a more limited role in the regulation of glycemic homeostasis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948212 | PMC |
| http://dx.doi.org/10.1007/s12020-019-02124-3 | DOI Listing |
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