AI Article Synopsis
- The study aimed to analyze how the radioligand F-PSMA-1007 behaves in the body and its effectiveness for detecting prostate cancer in patients experiencing biochemical relapse or progression.
- A total of 25 prostate cancer patients were assessed using dynamic and whole-body PET/CT scans, revealing that 15 of them tested positive for PET imaging of cancerous lesions.
- Results indicated that patients with higher PSA levels were more likely to test positive for prostate cancer, and dynamic PET scans showed increasing tracer accumulation in cancer lesions compared to other body areas during the imaging process.
Article Abstract
Objectives: Aim of the present analysis is to investigate the biodistribution and pharmacokinetics of the recently clinically introduced radioligand F-PSMA-1007 in patients with biochemical recurrence or progression of prostate cancer (PC) by means of multiparametric (dynamic and whole-body) PET/CT.
Methods: Twenty-five (25) patients with PC biochemical relapse or progression (median age = 66.0 years) were enrolled in the analysis. The median PSA value was 1.2 ng/mL (range = 0.1-237.3 ng/mL) and the median Gleason score was 7 (range = 6-10). All patients underwent dynamic PET/CT (dPET/CT) scanning (60 min) of the pelvis and lower abdomen as well as whole-body PET/CT with F-PSMA-1007. PET/CT assessment was based on qualitative evaluation, SUV calculation, and quantitative analysis based on a two-tissue compartment model and fractal analysis.
Results: 15/25 patients were PET-positive. Plasma PSA values in the F-PSMA-1007 positive group were higher (median = 3.6 ng/mL; range = 0.2-237.3 ng/mL) than in the F-PSMA-1007 negative group (median value = 0.7 ng/mL; range = 0.1-3.0 ng/mL). Semi-quantitative analysis in the PC lesions demonstrated a mean SUV = 25.1 (median = 15.4; range = 3.5-119.2) and a mean SUV = 41.5 (median = 25.7; range = 3.8-213.2). Time-activity curves derived from dPET/CT revealed an increasing tracer accumulation during the 60 min of dynamic PET acquisition into the PC lesions, higher than in the urinary bladder and the colon. Significant correlations were observed between F-PSMA-1007 uptake (SUV), influx, and fractal dimension (FD).
Conclusions: F-PSMA-1007 PET/CT could detect PC lesions in 60% of the patients of a mixed population, including also patients with very low PSA values. Higher PSA values were associated with a higher detection rate. Dynamic PET analysis revealed an increasing tracer uptake during the dynamic PET acquisition as well as high binding and internalization of the radiofluorinated PSMA ligand in the PC lesions.
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| http://dx.doi.org/10.1007/s00259-019-04569-0 | DOI Listing |
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