AI Article Synopsis
- The study investigates the genetic relationship between two IL23R polymorphisms (rs11209026 and rs10889677) and the risk of inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, through a meta-analysis of existing literature.
- It analyzes data from 41 studies involving over 13,000 patients with Crohn's disease and approximately 5,800 patients with ulcerative colitis, finding that certain genetic models significantly affect disease risk based on ethnicity.
- The results indicate that the rs11209026 polymorphism is generally associated with a decreased risk for both diseases, particularly in Caucasians, while the rs10889677 polymorphism appears to increase risks for both diseases, with results varying
Article Abstract
Objective: IL23R plays an important role in the pathogenesis of inflammatory bowel disease (IBD). The IL23R rs11209026 and rs10889677 polymorphisms have been shown to be associated with the development of Crohn's disease (CD) and ulcerative colitis (UC). But the results were inconsistent and inconclusive. So, we aim to investigate the genetic association between rs11209026 and rs10889677 polymorphisms and UC and CD risk by a meta-analysis.
Methods: Literature search was conducted through PubMed, CNKI, and web of science databases. Pooled OR and 95% CI was used to assess the association between the allelic, dominant and recessive models of IL23R rs11209026 and rs10889677 polymorphisms and UC and CD risk.
Results: 41 publications with 13,803 patients with CD and 17,446 controls, as well as 5876 patients with UC and 10,053 controls were included in the present study. All the genetic models of rs11209026 polymorphism significantly decrease CD and UC risk (except for the recessive model in UC) (p < 0.05). A subgroup analysis based on ethnicity showed that the allelic (p < 0.00001, OR = 0.65) and dominant models (p < 0.00001, OR = 0.61) of rs11209026 polymorphism were significantly associated with UC risk in Caucasians, but not in Asians (p > 0.05). In addition, the allelic (CD: p < 0.00001, OR = 1.34; UC: p < 0.00001, OR = 1.22) and dominant models (CD: p = 0.002, OR = 1.39; UC: p = 0.01, OR = 1.29), but not the recessive model of rs10889677 polymorphism significantly increase the risk of CD and UC (p > 0.05). A subgroup analysis showed that the genetic models of rs10889677 polymorphism were associated with CD risk in Caucasians (p < 0.05), but not in Asians (p > 0.05). The dominant model of rs10889677 polymorphism was associated with UC risk in Asians (p = 0.04, OR = 1.54), but not in Caucasians (p > 0.05).
Conclusions: Our meta-analysis demonstrated that the rs11209026 polymorphism might be a protective factor against developing IBD, while the rs10889677 polymorphism might be a risk factor for IBD.
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Article Synopsis
- The study investigates the genetic relationship between two IL23R polymorphisms (rs11209026 and rs10889677) and the risk of inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, through a meta-analysis of existing literature.
- It analyzes data from 41 studies involving over 13,000 patients with Crohn's disease and approximately 5,800 patients with ulcerative colitis, finding that certain genetic models significantly affect disease risk based on ethnicity.
- The results indicate that the rs11209026 polymorphism is generally associated with a decreased risk for both diseases, particularly in Caucasians, while the rs10889677 polymorphism appears to increase risks for both diseases, with results varying
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