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Neoadjuvant or perioperative immunotherapy for resectable melanoma: The need for biomarkers.
Eur J Cancer
January 2025
National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital, Herlev, Denmark. Electronic address:
Groundbreaking studies have reshaped the treatment landscape for patients with resectable stage ≥IIIB melanoma by demonstrating the benefits of neoadjuvant therapy. Data from the NADINA and SWOG S1801 trials reveal substantial improvements in event-free survival compared to adjuvant therapy alone. These studies employed distinct neoadjuvant immunotherapy approaches - ipilimumab plus nivolumab in NADINA and anti-PD-1 monotherapy in SWOG S1801 - highlighting potential differences in efficacy and toxicity.
View Article and Find Full Text PDFMapping the regional and remote specialised mental health workforce: Commentary on the AIHW data for 2022-2023.
Australas Psychiatry
January 2025
Consortium of Australian-Academic Psychiatrists for Independent Policy and Research Analysis (CAPIPRA), Canberra, ACT, Australia.
Objective: The Australian Institute of Health and Welfare publishes statistical indicator reports on the specialised mental health workforce. These include data for 2022-2023 on psychiatrists, mental health nurses, mental health occupational therapists, psychologists and mental health social workers. We provide a brief commentary on these reports, reflecting upon the implications of such changes for psychiatric practice and patient care.
View Article and Find Full Text PDFA Vote Against the Widespread Adoption of Primary Labral Reconstruction: Commentary on an article by Grant J. Dornan, MS, et al: "Two-Year Outcomes of Primary Arthroscopic Surgery in Patients with Femoroacetabular Impingement. A Comparative Study of Labral Repair and Labral Reconstruction".
J Bone Joint Surg Am
October 2024
Department of Orthopedic Surgery, University of Minnesota, Minneapolis, Minnesota.
Elegant and Innovative Recoding Strategies for Advancing Vaccine Development.
Vaccines (Basel)
January 2025
Department of Veterinary Microbiology and Immunology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E2, Canada.
Recoding strategies have emerged as a promising approach for developing safer and more effective vaccines by altering the genetic structure of microorganisms, such as viruses, without changing their proteins. This method enhances vaccine safety and efficacy while minimizing the risk of reversion to virulence. Recoding enhances the frequency of CpG dinucleotides, which in turn activates immune responses and ensures a strong attenuation of the pathogens.
View Article and Find Full Text PDFArtificial intelligence improves bronchoscopy performance: a randomised crossover trial.
ERJ Open Res
January 2025
Copenhagen Academy for Medical Education and Simulation, Rigshospitalet, The Capital Region of Denmark, Copenhagen, Denmark.
Rationale: Flexible bronchoscopy is an operator-dependent procedure. An automatic bronchial identification system based on artificial intelligence (AI) could help bronchoscopists to perform more complete and structured procedures through automatic guidance.
Methods: 101 participants were included from six different continents at the European Respiratory Society annual conference in Milan, 9-13 September 2023.
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