[Prevalence and characteristics of serum autoantibodies in patients followed for infertility at Grenoble University Hospital].

Presse Med

Centre hospitalier universitaire de Grenoble, service de médecine interne, 38000 Grenoble, France; Laboratoire de Biologie du Cancer et de l'Infection CEA-Grenoble, 38000 Grenoble, France.

Published: November 2019

AI Article Synopsis

  • Fertility disorders linked to autoimmune diseases are recognized, but the role of humoral serum autoimmunity in unexplained infertility is less understood.
  • A study was conducted on patients with infertility, dividing them into two groups based on the presence of serum autoimmunity, with significant findings in each group.
  • Results showed that 33% of patients exhibited autoimmunity, with those in the AI+ group experiencing higher pregnancy rates during immunomodulatory therapy compared to the AI- group, suggesting potential benefits of this treatment approach.

Article Abstract

Introduction: Fertility disorders in autoimmune diseases are well described. However, little is known about the presence of a humoral serum autoimmunity in case of infertility (antinuclear antibodies, ACAN or antiphospholipid, APL) without criteria of autoimmune disease.

Methods: We studied the prevalence, associated factors, and efficacy of immunomodulatory therapy in patients with unexplained infertility. Two groups were created retrospectively among patients followed in medically assisted procreation (PMA) for infertility: a group with serum autoimmunity (AI+) (ACAN, APL or anti-thyroperoxidase antibodies) and a group without serum autoimmunity (HAVE-). Clinical, biological, and therapeutic data were collected.

Results: The prevalence of autoimmunity was 33% among consultant patients. One hundred patients were seen in internal medicine consultation, 70 were included in the AI+ group and 30 in the AI- group. In the AI+ group, 76% had ACANs, 29% had anti-TPOs and 23% had APLs. There was a significant correlation between ACAN level and the presence of endometriosis (P=0.048). Immunomodulatory therapy was introduced for 68 of the 70 women in the AI+ group; pregnancy occurred in 28 patients (40%) during the treatment period, compared with 7 in the "AI-" group (23%), with a tendency to significance (P=0.09). In conclusion, there is an increased prevalence of serum autoimmunity in patients with fertility disorders, possibly with the efficacy of an immunomodulatory treatment to confront prospective therapeutic studies.

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Source
http://dx.doi.org/10.1016/j.lpm.2019.10.002DOI Listing

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