and antioxidant activity profiles of urea and thiourea derivatives of 5-hydroxytryptophan.

A series of new urea and thiourea derivatives of 5-hydroxy tryptophan was designed and synthesized from 5-hydroxy tryptophan () by treating various isocyanates and isothiocyanates in the presence of triethylamine (TEA) as a base. The antioxidant activities of the newly synthesized compounds were evaluated by using different assays such as 1, 1-diphenyl-2-picrylhydrazyl (DPPH), hydrogen peroxide (HO) and superoxide. The results obtained from the studies revealed that the compounds , , , and exhibited the significant high content of antioxidant activity. Besides, molecular docking studies indicated that, all the compounds have formed higher binding energies with 3MNG protein than the reference compound . Among all the synthesized compounds, , , , , and have exhibited the highest dock scores than the rest of the compounds including the reference compound. Hence, it is concluded that the title compounds will open new vistas for the discovery of strong antioxidants and will stand as remarkable antioxidant moieties in future.