Larotrectinib can be effective in patients with ETV6-NTRK3–positive B-cell lymphoblastic leukemia, inducing prolonged molecular remission. Single-agent tyrosine kinase inhibitor treatment could be a valuable treatment option in subgroups of kinase fusion–positive ALL patients.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880891PMC
http://dx.doi.org/10.1182/bloodadvances.2019000700DOI Listing

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