An ɑ-adrenergic receptor is involved in larval metamorphosis in the mussel, .

Metamorphosis is crucial in the life-cycle transition between the larval and juvenile stages of marine invertebrates. Although a number of agonists and antagonists of the adrenergic receptor (AR) are known to regulate larval metamorphosis in (Mc), the molecular basis of the modulation of larval metamorphosis by the AR gene in this species remains elusive. Herein, the role of the AR gene in larval metamorphosis using the RNA interference technique was examined. The McαAR transcript was observed to be present during the entire process of larval development and its level in the post-larvae was significantly increased compared to that in the pediveligers. McαAR-knockdown resulted in a substantial reduction in the abundance of the McαAR transcript and significantly inhibited the metamorphosis of larvae. These findings provide new insights into the molecular basis of modulation of larval metamorphosis in by the AR gene.