New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata.

Nat Prod Bioprospect

BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China.

Published: December 2019

AI Article Synopsis

  • Two new iboga-type indole alkaloids were identified from the twigs and leaves of the Tabernaemontana divaricata plant.
  • The newly discovered compounds are (3R)-7,19-di-epi-3-methoxytabernoxidine and (3R,19R)-19-hydroxy-3-(2-oxopropyl)voacangine.
  • Their structural identities were confirmed through various scientific methods, including spectroscopic techniques, X-ray diffraction, and circular dichroism analysis.

Article Abstract

Two hitherto unknown iboga-type indole alkaloids, namely (3R)-7,19-di-epi-3-methoxytabernoxidine (1) and (3R,19R)-19-hydroxy-3-(2-oxopropyl)voacangine (2), together with eight known alkaloids (3-10), were isolated from the twigs and leaves of Tabernaemontana divaricata. Their structures were established on the basis of spectroscopic data interpretation, single crystal X-ray diffraction analysis and circular dichroism spectrum.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872691PMC
http://dx.doi.org/10.1007/s13659-019-00226-zDOI Listing

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