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Machine learning-driven risk assessment of coronary heart disease: Analysis of NHANES data from 1999 to 2018.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
August 2024
Department of Cardiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009.
Objectives: The high incidence of coronary artery heart disease (CHD) poses a significant burden and challenge to public health systems globally. Effective prevention and early diagnosis of CHD have become key strategies to alleviate this burden. This study aims to explore the application of advanced machine learning techniques to enhance the accuracy of early screening and risk assessment for CHD.
View Article and Find Full Text PDFThe Impact of Evolving Endometriosis Guidelines on Diagnosis and Observational Health Studies.
medRxiv
December 2024
Department of Biomedical Informatics, Columbia University, New York, NY, USA.
Study Question: Do recent changes in European Society of Human Reproduction and Embryology (ESHRE) clinical guidelines result in more comprehensive diagnosis of women with endometriosis?
Summary Answer: The latest shift in clinical guidelines results in diagnosis of more women with endometriosis but current ESHRE diagnostic criteria do not capture a sizable percentage of women with the disease.
What Is Known Already: Historically, laparoscopy was the gold standard for diagnosing endometriosis, a complex gynecological condition marked by a heterogeneous set of symptoms that vary widely among women. More recently, changes in clinical guidelines have shifted to incorporate imaging-based approaches such as transvaginal sonography and magnetic resonance imaging.
Clinical, Biochemical and Molecular Characteristics of Congenital Adrenal Hyperplasia Due to 21-hydroxylase Deficiency.
J Clin Res Pediatr Endocrinol
January 2025
Ankara University Faculty of Medicine, Department of Pediatric Endocrinology, Ankara, Turkey
Congenital adrenal hyperplasia (CAH) is an autosomal recessive disease caused by the deficiency of one of the enzymes involved in cortisol synthesis. Between 90% and 99% of cases of CAH are caused by 21-hydroxylase deficiency (21-OHD) caused by mutations in . Although 21-OHD has been historically divided into classical and non-classical forms, it is now thought to show a continuous phenotype.
View Article and Find Full Text PDFThe search to understand the development of the chicken immune system: Differences in expression of MHC class I loci and waves of thymocytes as evolutionary relics?
Dev Biol
December 2024
University of Edinburgh, Institute for Immunology and Infection Research, Edinburgh, United Kingdom. Electronic address:
Chickens are renowned as a model for embryogenesis but have also been responsible for crucial advances in virology, cancer research and immunology. However, chickens are best known as a major source of animal protein for human nutrition, with roughly 80 billion chickens alive each year supplying meat and eggs, the vast majority part of a global poultry industry. As a result, avian immunology been studied intensively for over 60 years, and it has become clear that a major genetic locus in chickens determining resistance to infectious disease and response to vaccines is the major histocompatibility complex (MHC).
View Article and Find Full Text PDFHLA-G liver expression in chronically HIV/hepatitis C-coinfected individuals.
Ann Hepatol
December 2024
Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. Electronic address:
Article Synopsis
- Hepatitis C (HCV) in people who are also infected with HIV leads to faster liver disease progression compared to those with only HCV, potentially due to HLA-G, which suppresses immune responses.
- A study analyzed liver samples from 59 patients with both chronic HCV and HIV to look at HLA-G levels in relation to liver disease severity.
- The results showed that higher HLA-G expression was linked to more severe liver conditions but did not affect the effectiveness of HCV treatment, indicating HLA-G's complex role in disease progression in coinfected patients.
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