AI Article Synopsis
- Researchers developed a new test called Fibrinography to assess the structure of fibrin fibers in plasma, expanding its application beyond a pure fibrinogen-thrombin system to include tissue factor-triggered coagulation.
- Fibrinography provides reliable measurements of fibrin fiber structure, outperforming the traditional turbidity method, which primarily measures fibrinogen levels rather than fiber structure.
- The test can effectively differentiate between normal, hypocoagulant, and hypercoagulant plasmas, making it useful for diagnosing clotting disorders in patients.
Article Abstract
We have previously developed a fibrin structural assay dedicated to purified fibrinogen-thrombin system. Here, we extend the pertinence of this test, called Fibrinography, to tissue factor-triggered plasma coagulation. We show that Fibrinography determines quantitatively the structure of fibrin fibers in plasma with an excellent reproducibility. We compare this assay with the commonly used single wavelength turbidity method, showing that the latter is not a proper structural assay, but determines essentially the fibrinogen content in plasma. In addition, we also show, in model plasmas, that Fibrinography is able to discriminate normal and hypocoagulant plasmas, and even between hypercoagulant plasmas. Therefore, Fibrinography, by measuring the final step of the coagulation cascade, may be used to evaluate patients' plasma in hypo- or hypercoagulant diseases.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745935 | PMC |
| http://dx.doi.org/10.1097/HS9.0000000000000166 | DOI Listing |
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