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Clinical Effects and Response Time of Biological Drugs in Chronic Rhinosinusitis with Nasal Polyps Patients: Real-life Experience.
Laryngoscope
December 2024
ENT Department, Misericordia Hospital, Grosseto, Italy.
Objective: Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is a challenging condition often managed with biologic therapies. This study compares the clinical effects and response times of dupilumab, omalizumab, and mepolizumab in Italian patients with severe uncontrolled CRSwNP.
Methods: This bicentric, retrospective study included 33 patients treated at two Italian hospitals between April and December 2023.
The detection of GRN mutation carriers by progranulin blood protein levels from finger-stick collection.
Alzheimers Dement
November 2024
Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Introduction: Heterozygous mutations in the progranulin gene (GRN) leading to decreased progranulin levels are one of the most frequent causes of inherited frontotemporal dementia (FTD). We evaluated progranulin levels in dried blood spots from capillary finger-stick collection (DBS).
Methods: Paired venous Ethylenediaminetetraacetic acid (EDTA) plasma and DBS samples were collected from each participant with or without pathogenic GRN mutations.
Factors Associated With Needle Stick Injuries Among Healthcare Workers: A Retrospective Study in a Tertiary Care Hospital of Eastern India.
Cureus
October 2024
Medicine, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.
Article Synopsis
- Needle stick injuries (NSIs) pose serious health risks for healthcare workers, exposing them to blood-borne infections like HIV, HBV, and HCV; this study analyzed NSI cases over four years from a hospital in India.
- The study recorded 115 NSI cases from 2019 to 2022, with a higher incidence among younger healthcare workers, especially nurses in the initial years, while housekeeping staff were more affected in later years; most injuries occurred during morning shifts and in the inpatient department.
- Post-exposure prophylaxis was administered to a subset of affected workers, with a negative HIV serology status for all tested, although some cases showed positive for HBV and HCV.
In-human clinical experience with direct stick embolization of low-flow vascular malformations using a mammalian target of rapamycin inhibitor.
J Vasc Surg Venous Lymphat Disord
November 2024
The Vascular Care Group (TVCG), Darien, CT; Vascular Anomalies and Malformations Program (VAMP), Yale School of Medicine, New Haven, CT; Division of Vascular Surgery, Department of Surgery, Yale New Haven Health, New Haven, CT. Electronic address:
Background: Although direct stick embolization (DSE) of low-flow vascular malformations (LFVMs) with off-label embolotherapeutic compounds is the current mainstay of therapy, systemic oral mammalian target of rapamycin (mTOR) inhibition has evolved into an important adjunctive therapy that is associated with frequent blood draws, systemic toxicity, and rebound signs and symptoms upon cessation. We herein report our experience with in-human DSE of LFVMs with an mTOR inhibitor for direct, intralesional targeting of the culprit mutated pathway without repeated systemic exposure.
Methods: Since 2020, 33 procedures involving DSE were performed in 25 patients with LFVMs using a patented formulation and technique involving the intravenously compatible mTOR inhibitor Yale-OCR7737, used as a liquid compound in a collagen matrix emulsion for added viscosity and intralesional residence.
Systematic review of oral health in slums and non-slum urban settings of Low and Middle-Income Countries (LMICs): Disease prevalence, determinants, perception, and practices.
PLoS One
November 2024
Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, United Kingdom.
Article Synopsis
- A systematic review was conducted to summarize the latest evidence on oral health issues in slum areas, highlighting the disease burden, perceptions, practices, and access to services in both slum and non-slum urban environments of low and middle-income countries (LMICs).
- The review included studies published from January 2000 to June 2023 and utilized comprehensive databases, focusing on empirical research that reported on oral health among slum residents.
- Out of 56 assessed articles, 23 were included in the review, primarily from Asia (57%) and Africa (39%), with a varied focus on slums and urban settings to better inform health policy.
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