Object recognition memory (ORM) serves to distinguish familiar items from novel ones. Reconsolidation is the process by which active memories are updated. The hippocampus is engaged in ORM reconsolidation through a mechanism involving induction of long-term potentiation (LTP). The transcription factor Zif268 is essential for hippocampal LTP maintenance and has been frequently associated with memory processes. However, its possible involvement in ORM reconsolidation has not been determined conclusively. Using Zif268 antisense oligonucleotides in combination with behavioural, biochemical and electrophysiological tools in rats, we found that hippocampal Zif268 is necessary to update ORM through reconsolidation but not to retrieve it or keep it stored. Our results also suggest that knocking down hippocampal Zif268 during ORM reconsolidation deletes the active recognition memory trace.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851087 | PMC |
| http://dx.doi.org/10.1038/s41598-019-53005-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
NMDARs control object recognition memory destabilization and reconsolidation.
Brain Res Bull
June 2023
Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte, 59078-900 Natal, RN, Brazil. Electronic address:
Object recognition memory (ORM) allows identification of previously encountered items and is therefore crucial for remembering episodic information. In rodents, reactivation during recall in the presence of a novel object destabilizes ORM and initiates a Zif268 and protein synthesis-dependent reconsolidation process in the hippocampus that links the memory of this object to the reactivated recognition trace. Hippocampal NMDA receptors (NMDARs) modulate Zif268 expression and protein synthesis and regulate memory stability but their possible involvement in the ORM destabilization/reconsolidation cycle has yet to be analyzed in detail.
View Article and Find Full Text PDFOn the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory.
Front Behav Neurosci
December 2022
Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
c-Jun N-terminal kinase (JNK) phosphorylates the transcription factor c-Jun in response to stress stimuli and contributes to both hippocampal synaptic plasticity and memory processing in mammals. Object recognition memory (ORM) is essential for remembering facts and events. In rodents, ORM consolidation and reconsolidation require a functional hippocampus.
View Article and Find Full Text PDFThe role of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type receptor modulators in object recognition memory reconsolidation.
Neuroreport
March 2022
The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang.
Objective: Numerous studies suggest that the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type (AMPA) receptor appears to play a central role in mediating brain functions, such as learning and memory. Trafficking of this receptor is related to different long-term memory processes. This study explores the role of two AMPA receptor (AMPAR) modulators in object recognition memory (ORM) reconsolidation.
View Article and Find Full Text PDFReactivation-dependent amnesia for object recognition memory is contingent on hippocampal theta-gamma coupling during recall.
Learn Mem
January 2022
Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte, Natal 59076-550, Brazil.
Hippocampal dopamine D1/D5 receptor-dependent destabilization is necessary for object recognition memory (ORM) updating through reconsolidation. Dopamine also regulates hippocampal theta and gamma oscillations, which are involved in novelty and memory processing. We found that, in adult male rats, ORM recall in the presence of a novel object, but not in the presence of a familiar one, triggers hippocampal theta-gamma coupling.
View Article and Find Full Text PDFUrocanic acid enhances memory consolidation and reconsolidation in novel object recognition task.
Biochem Biophys Res Commun
November 2021
School of Basic Medical Sciences, Shaoyang University, Shaoyang, 422000, PR China; Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow, G4 0BA, UK; Department of Vision Science, Glasgow Caledonian University, Glasgow, G4 0BA, UK. Electronic address:
Urocanic acid (UCA) is an endogenous small molecule that is elevated in skin, blood and brain after sunlight exposure, mainly playing roles in the periphery systems. Few studies have investigated the role of UCA in the central nervous system. In particular, its role in memory consolidation and reconsolidation is still unclear.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!