Inflammation of renal interstitium and uveal tissue establishes the two components of tubulointerstitial nephritis and uveitis (TINU) syndrome. Although believed to occur more frequently in young females, a broad spectrum of patients can be affected. Both renal and eye disease can be asymptomatic and may not manifest simultaneously, having independent progressions. Renal disease manifests as acute kidney injury and may cause permanent renal impairment. Eye inflammation can manifest in different anatomical forms, most commonly as bilateral anterior uveitis and may progress to a chronic course. TINU syndrome accounts for approximately 1%-2% of uveitis in tertiary referral centres. A literature review covering the clinical features, pathogenesis, diagnosis and treatment is presented.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1136/bjophthalmol-2019-314926 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Autoimmune Tubulopathies.
J Am Soc Nephrol
January 2025
Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université Paris Cité, F-75006 Paris, France.
The renal tubule and collecting duct express a large number of proteins, all having putative immunoreactive motives. Therefore, all can be the target of pathogenic autoantibodies. However, autoimmune tubulopathies seem to be rare and we hypothesize that they are underdiagnosed.
View Article and Find Full Text PDFTubulointerstitial Nephritis and Uveitis Syndrome Presenting with Scleritis.
Ocul Immunol Inflamm
September 2024
Connecticut Uveitis Foundation, West Hartford, Connecticut, USA.
Purpose: To report two patients who presented with scleritis associated with tubulointerstitial nephritis and uveitis syndrome (TINU).
Results: A 13-year-old male initially presenting with unilateral panuveitis with scleritis in the fellow eye was ultimately diagnosed with TINU. A 33-year-old male previously diagnosed with TINU presented with recurrent bilateral episcleritis as well as bilateral scleritis eight years after his first episode of bilateral anterior uveitis.
Adalimumab to treat noninfectious pediatric chronic anterior uveitis: a case series.
Int Ophthalmol
September 2024
Department of Ophthalmology, Foster Center for Ocular Immunology at Duke Eye Center, Duke University School of Medicine, Durham, NC, USA.
Article Synopsis
- The study aimed to evaluate the effectiveness of adalimumab (ADA) in treating pediatric chronic anterior uveitis (pCAU) by reviewing patient charts and assessing outcomes like inflammation reduction and visual acuity.
- Out of 27 children studied, 78% achieved remission, with notable racial differences showing that African American children experienced worse visual outcomes and higher recurrence rates of uveitis compared to Caucasian children.
- Overall, ADA was effective in managing inflammation and reducing reliance on corticosteroids, but the findings highlighted the need for further research to address the racial disparities in treatment outcomes.
Tubulointerstitial Nephritis and Uveitis in a Pediatric Patient.
Cureus
August 2024
Pediatric Rheumatology, Child and Youth Department, Hospital Professor Doutor Fernando Fonseca, Lisboa, PRT.
Tubulointerstitial nephritis and uveitis syndrome (TINU) is a rare autoimmune disease. It is characterized by uveitis and kidney damage. The presentation of uveitis is typically anterior and bilateral, while the renal lesion is an acute interstitial nephritis.
View Article and Find Full Text PDFTubulointerstitial Nephritis and Uveitis Syndrome: A Case Report.
Cureus
August 2024
Rheumatology, First Person Care Clinic, Las Vegas, USA.
Tubulointerstitial nephritis and uveitis (TINU) syndrome is an uncommon autoimmune disorder that is defined by tubulointerstitial nephritis and uveitis. It is frequently underdiagnosed or goes unrecognized due to the challenges of accurately diagnosing the syndrome. TINU has mostly been seen among female pediatric patients with primarily bilateral anterior uveitis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!