AI Article Synopsis
- The study reviews the DAIR procedure as a treatment for periprosthetic knee infections (PKI), aiming to evaluate its success and develop a prediction algorithm.
- An analysis of 33 studies with 1266 cases showed an overall success rate of 57.11%, with significant improvement for cases where symptoms started less than 3 weeks before debridement and bacterial species were not methicillin-resistant Staphylococcus aureus.
- The proposed algorithm suggests that PKI patients meeting two major criteria and at least one minor criterion have an 80.98% success rate with DAIR, helping to identify suitable candidates for this treatment.
Article Abstract
Background: The debridement, antibiotics, and implant retention (DAIR) procedure is an established therapeutic option for periprosthetic knee infections (PKI). However, the efficacy and the indication for this procedure are still controversial.
Methods: All the relevant literatures were systematically reviewed and analyzed. The present study aimed to assess the success rate of DAIR in the management of PKI, identify the factors associated with prognosis of DAIR, and establish a simple algorithm for predicting a high success rate of DAIR.
Results: Totally, 33 studies with 1266 cases were included. The overall success rate following DAIR in the management of PKI was 57.11%. In the subgroup analyses, the factors of "the time from symptoms to debridement was < 3 weeks" and "the bacterial species other than methicillin-resistant Staphylococcus aureus" significantly improved the success rate of DAIR and thus were defined as the major criteria. The statistically insignificant factors of "the open debridement and liner exchange" and "the comorbidity of rheumatoid arthritis" were set as the minor criteria. The success rate of DAIR for PKI meeting all the major criteria and no less than one minor criterion was 80.98%, which was significantly higher than the overall success rate of DAIR (p < 0.05).
Conclusion: PKI cases meeting two major criteria and no less than one minor criterion may confer a high success rate of DAIR. This simple algorithm may contribute to identifying the appropriate PKI patient for DAIR treatment and predicting the prognosis of DAIR.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852904 | PMC |
| http://dx.doi.org/10.1186/s13018-019-1378-4 | DOI Listing |
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