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A new framework for characterization of poroelastic materials using indentation. | LitMetric

A new framework for characterization of poroelastic materials using indentation.

Acta Biomater

Department of Mechanical Engineering, University College London, London, United Kingdom; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States. Electronic address:

Published: January 2020

AI Article Synopsis

Article Abstract

To characterize a poroelastic material, typically an indenter is pressed onto the surface of the material with a ramp of a finite approach velocity followed by a hold where the indenter displacement is kept constant. This leads to deformation of the porous matrix, pressurization of the interstitial fluid and relaxation due to redistribution of fluid through the pores. In most studies the poroelastic properties, including elastic modulus, Poisson ratio and poroelastic diffusion coefficient, are extracted by assuming an instantaneous step indentation. However, exerting step like indentation is not experimentally possible and usually a ramp indentation with a finite approach velocity is applied. Moreover, the poroelastic relaxation time highly depends on the approach velocity in addition to the poroelastic diffusion coefficient and the contact area. Here, we extensively studied the effect of indentation velocity using finite element simulations which has enabled the formulation of a new framework based on a master curve that incorporates the finite rise time. To verify our novel framework, the poroelastic properties of two types of hydrogels were extracted experimentally using indentation tests at both macro and micro scales. Our new framework that is based on consideration of finite approach velocity is experimentally easy to implement and provides a more accurate estimation of poroelastic properties. STATEMENT OF SIGNIFICANCE: Hydrogels, tissues and living cells are constituted of a sponge-like porous elastic matrix bathed in an interstitial fluid. It has been shown that these materials behave according to the theory of 'poroelasticity' when mechanically stimulated in a way similar to that experienced in organs within the body. In this theory, the rate at which the fluid-filled sponge can be deformed is limited by how fast interstitial fluid can redistribute within the sponge in response to deformation. Here, we simulated indentation experiments at different rates and formulated a new framework that inherently captures the effects of stimulation speed on the mechanical response of poroelastic materials. We validated our framework by conducting experiments at different length-scales on agarose and polyacrylamide hydrogels.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958526PMC
http://dx.doi.org/10.1016/j.actbio.2019.11.010DOI Listing

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