The aim - of the study was to study the effectiveness of Remaxol in the correction of homeostasis disorders in patients with acute peritonitis after laparotomic surgery intervention.
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http://dx.doi.org/10.17116/hirurgia201911169 | DOI Listing |
Background: Sleep disturbances have been identified as a risk factor for developing dementia. The hypothalamus is involved in sleep regulation and may be affected early by neurodegeneration. Our aim was to investigate the relationship between subjective sleep and hypothalamic structure in adults at higher risk of developing dementia.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: The G protein-coupled receptor GPR39 is heavily associated with the pathogenesis of neurologic disorders, including Alzheimer's disease (AD) and related dementia (ADRD). Its dysregulation of zinc 2+ (Zn) processes triggers metallic dyshomeostasis, oxidative stress, neuroinflammation, microtubule destabilization, synaptic dysfunction, and tau phosphorylation-all hallmarks of neurodegeneration. Hence, pharmacologic modulation of GPR39 could offer an effective treatment against AD and ADRD.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin - Institute of Psychiatry and Psychotherapy, Berlin, Berlin, Germany.
Background: Mechanisms of cellular senescence affecting neuroimmune responses, homeostasis, and synaptic functioning associate with core Alzheimer's disease (AD) biomarkers, i.e., pathological aggregation of β-amyloid (Aβ) and tau protein, while their longitudinal associations remain unclear.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Background: Purinergic signaling is vital in various cellular processes like neuroinflammation, synaptic transmission, Aβ clearance, and tau phosphorylation regulation. This study aims to examine if SNPs in purinergic signaling genes are associated to A/T(N) status biomarkers in Alzheimer's Disease through Genome Wide Association Studies.
Method: The SNPRelate package was used to analyze SNPs in genes related to purinergic signaling and A/T(N) markers.
Alzheimers Dement
December 2024
Alzheimer's Clinical Trial Consortium, Boston, MA, USA.
Background: Amyloid deposition occurs during the preclinical stages of Alzheimer's disease (AD) a decade or more before clinical symptoms emerge. We leveraged blood transcriptomics and positron emission tomography (PET) measures of amyloidosis to identify cell types and gene networks in the blood that relate to amyloid burden in the brain.
Method: Whole blood RNA sequencing and amyloid PET data were leveraged from 1771 participants (62% females, mean age 71, 32% amyloid+) in the Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) Study.
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