Purpose: To determine diagnostic validity of cardiopulmonary exercise testing (CPX) parameters for detecting pulmonary hypertension (PH) in patients with chronic obstructive pulmonary disease (COPD) and to investigate association between CPX parameters and indices of PH.
Methods: This cross-sectional study enrolled 48 moderate to very severe COPD patients in whom PH was confirmed by echocardiography. Symptom-limited CPX was performed using an incremental exercise protocol. Relevant CPX parameters were derived and were tested for their diagnostic ability for diagnosing PH. Logistic regression was applied to examine the effect of various clinical covariates on the diagnostic ability of exercise test variables for detecting PH.
Results: Of the 48 patients, 29 were diagnosed with PH and 19 were negative for PH based on echocardiographic testing. CPX measures including peak oxygen uptake (% predicted (Equation is included in full-text article.)O2peak, (Equation is included in full-text article.)O2peak [mL/min], (Equation is included in full-text article.)O2/kg), oxygen pulse ((Equation is included in full-text article.)O2/HR % predicted, (Equation is included in full-text article.)O2/HR mL/beat), and peak minute ventilation ((Equation is included in full-text article.)Epeak [L/m]) were inversely correlated with mean pulmonary arterial pressure (mPAP). Peak (Equation is included in full-text article.)O2/HR and (Equation is included in full-text article.)O2peak were found to be significant predictors of PH in univariate analysis. (Equation is included in full-text article.)O2peak (%), (Equation is included in full-text article.)O2/HR (mL/beat), and desaturation (%) were identified as independent predictors of PH adjusted for age, forced expiratory volume in 1 sec (%), and forced vital capacity (L).
Conclusion: The present study validates the use of CPX parameters such as (Equation is included in full-text article.)O2peak and (Equation is included in full-text article.)O2/HR as a diagnostic tool for correctly identifying PH in COPD patients. Therefore, CPX may be used as an adjunct to echocardiographic measurement of PH where there is unavailability of equipment and expertise.
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http://dx.doi.org/10.1097/HCR.0000000000000456 | DOI Listing |
J Clin Hypertens (Greenwich)
January 2025
Department of Noncommunicable Diseases, Bangladesh University of Health Sciences (BUHS), Dhaka, Bangladesh.
This population-based, nationally representative cross-sectional study assessed the daily salt consumption status and its associated cardiovascular disease (CVD) risk factors using weighted data from the STEPwise approach to noncommunicable disease risk factor surveillance conducted in 2018 in Bangladesh. It included a non-institutionalized adults' population of 6189 men and women aged 18-69 years. Their daily salt consumption was estimated using the spot urine sodium concentration following the Tanaka equation and reported according to the standard nomenclature proposed by the World Hypertension League and partner organizations involved in dietary salt reduction.
View Article and Find Full Text PDFJ Clin Hypertens (Greenwich)
January 2025
Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Evidence suggests that approximately 63.0%-84.2% of stroke survivors have hypertension, yet there is currently no stroke prediction tool specifically designed for individuals with hypertension.
View Article and Find Full Text PDFJ Math Biol
January 2025
School of Mathematics and Statistics, Northeast Normal University, 5268 Renmin Street, Changchun, 130024, Jilin, People's Republic of China.
Wild birds are one of the main natural reservoirs for avian influenza viruses, and their migratory behavior significantly influences the transmission of avian influenza. To better describe the migratory behavior of wild birds, a system of reaction-advection-diffusion equations is developed to characterize the interactions among wild birds, poultry, and humans. By the next-generation operator, the basic reproduction number of the model is formulated.
View Article and Find Full Text PDFNeurocrit Care
January 2025
Department of Neurosurgery, The Johns Hopkins University School of Medicine, 1800 Orleans Street, Baltimore, MD, 21287, USA.
Background: Traumatic brain injury (TBI) is a significant cause of morbidity and mortality in the older adult population, and palliative care consultation can assist in goals-of-care discussions. However, patterns of hospital care delivered before consultation are understudied for older adult patients with TBI. The objective of this study was to identify demographic and clinical drivers of preconsultation care intensity in this population.
View Article and Find Full Text PDFJ Antimicrob Chemother
January 2025
Institute for Hygiene and Environmental Medicine, Charité-Universitätsmedizin Berlin, Joint institution of Freie Universität Berlin and Humboldt-Universität Berlin, Institut für Hygiene und Umweltmedizin, Campus Benjamin Franklin, Hindenburgdamm 27, 12203 Berlin, Germany.
Background: Antibiotic consumption is considered an important risk factor for Clostridioides difficile infection (CDI). This ecological analysis investigates the influence of outpatient antibiotic prescriptions in statutory health insurance (SHI) on the admission prevalence of CDI in German hospitals participating in voluntary CDI surveillance through the hospital infection surveillance system (Krankenhaus-Infektions-Surveillance-System; KISS).
Methods: The annual CDI admission prevalence of a hospital at the federal state level was associated with the outpatient antibiotic consumption of the corresponding federal state.
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