AI Article Synopsis
- Researchers identified and characterized a new flavonol compound, opuntiol, from cactus pads using chromatography and various spectroscopy methods.* -
- The structure of opuntiol was determined to be near planar and stabilized by specific hydrogen bonds, as shown through single-crystal X-ray diffraction.* -
- Opuntiol demonstrated significant anti-proliferative effects on KB cancer cells, inducing ROS generation and apoptosis, with an inhibition concentration (IC) value of 30 µM.*
Article Abstract
In this study, we isolated and characterized a novel bioactive flavonol from the cactus pad of Indica (L. Mill) (OFI) by chromatography techniques. The isolated compound was characterized by FT-IR, H and C NMR spectroscopy. Single-crystal XRD results illustrate that the obtained flavonol was opuntiol (6-hydroxymethyl-4-methoxy-2-pyran-2-one) and it was found to be near planar except for the H atoms of the methylene and methyl groups. The crystal packing was stabilized by C-H….O and O-H….O intermolecular hydrogen bonds. The isolated opuntiol significantly inhibited KB cells proliferation and its IC value was found to be 30 µM. Further, we noticed that opuntiol significantly induced ROS generation and subsequently altered MMP in KB cells. Western blot analysis and morphological observations by fluorescence microscope indicate the apoptotic inducing potential of opuntiol in KB cells.
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| http://dx.doi.org/10.1080/14786419.2019.1690484 | DOI Listing |
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