AI Article Synopsis
- The study investigated if vitamin D supplementation enhances the effectiveness of pegylated interferon-α plus ribavirin treatment in chronic hepatitis C patients.
- A total of 148 patients were divided into two groups: one receiving standard treatment and the other receiving the same treatment plus daily vitamin D.
- Results showed a slight increase in the sustained virologic response rate in the vitamin D group, but it was not statistically significant, indicating vitamin D does not improve treatment outcomes for chronic hepatitis C.
Article Abstract
Background/aims: We aimed to assess the role of vitamin D supplementation in the response to pegylated interferon-α (PEG-IFN-α) plus ribavirin (RBV) treatment in patients with chronic hepatitis C (CHC).
Methods: Our study was a multi-center, randomized controlled trial in 11 hospitals. CHC patients were randomly assigned (1:1) to two groups namely, PEGIFN-α plus RBV (control group) or PEG-IFN-α plus RBV + vitamin D (800 IU daily) (vitamin D group). The primary end-point was the rate of sustained virologic response (SVR).
Results: One hundred forty eight CHC patients were randomly assigned to two groups. Seventy-one patients received the PEG-IFN-α plus RBV and 77 patients received the PEG-IFN-α plus RBV + vitamin D. A total of 105 patients completed the study (control group, 47 vs. vitamin D group, 58). Baseline characteristics were mostly similar in both the groups. There was a modest but non-significant increase in SVR in the vitamin D group compared to the control group with the intention to treat analysis (64.0% vs. 49.3 %, p = 0.071) as well as in the per protocol analysis (control group vs. vitamin D group: 74.5% vs. 84.5%, p = 0.202). Fifty-two patients (73.2%) in the control group and 63 patients (81.8%) in the vitamin D group experienced at least one adverse event. The drop-out rate due to adverse effects was not different between both groups (control group vs. vitamin D group: 19.7% vs. 10.4%, p = 0.111).
Conclusion: Vitamin D supplement did not increase SVR in treatment naïve patients with CHC irrespective of genotype.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487303 | PMC |
| http://dx.doi.org/10.3904/kjim.2018.273 | DOI Listing |
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