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Cancer-Associated Retinopathy and Treatment with Intravenous Immunoglobulin Therapy. A Seldom Used Approach? | LitMetric

AI Article Synopsis

  • A 68-year-old woman with cancer-associated retinopathy (CAR) experienced a month-long decline in vision, which led to the discovery of retinal atrophy and the diagnosis of small cell lung carcinoma related to anti-recoverin antibodies.
  • The treatment approach included corticosteroids and intravenous immunoglobulin (IGIV), which helped stabilize her visual loss.
  • A literature review revealed only 12 similar CAR cases treated with IGIV, suggesting that early IGIV use may improve or stabilize visual symptoms while minimizing adverse effects when combined with chemotherapy.

Article Abstract

: To report a case of cancer-associated retinophaty (CAR) treated with intravenous immunoglobulin (IGIV) and review the use of IGIV in the treatment of CAR: Case report: A 68-year-old woman, former smoker, presented with bilateral subacute decreased visual acuity with 1 month of evolution, without other symptoms. Clinical examination revealed retinal atrophy and a mild vitritis component. Treatment with corticosteroid and IGIV was initiated empirically with the stabilization of visual loss. Anti-recoverin antibodies tested positive and a small cell lung carcinoma was diagnosed. In a review of the literature, we found that only 12 cases of patients treated with intravenous immunoglobulins have been reported.: the early use of IVIG could contribute to an improvement and/or stabilization of visual symptoms in this patient group due to its rapid effect and lower profile of adverse effects when administered with chemotherapy.

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Source
http://dx.doi.org/10.1080/09273948.2019.1681471DOI Listing

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