Nonadride and Spirocyclic Anhydride Derivatives from the Plant Endophytic Fungus .

J Nat Prod

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica , Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050 , People's Republic of China.

Published: November 2019

Six new nonadride derivatives (-) and three new spirocyclic anhydride derivatives (-) were isolated from the endophytic fungus obtained from fresh leaves of the toxic medicinal plant The structures of these compounds were determined by spectroscopic analyses including 1D and 2D NMR, HRESIMS, and ECD techniques. Maleic anhydride derivatives - were evaluated for their anti-inflammatory activities. Compound showed significant inhibitory activity against NO production in LPS-induced RAW264.7 cells with an IC value of 1.9 μM. Compounds and showed moderate inhibitory activities toward XOD and PTP1b, respectively, at 10 μM with inhibition rates of 67% and 76%.

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Source
http://dx.doi.org/10.1021/acs.jnatprod.9b00210DOI Listing

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