Herein, we report a highly selective C-H olefination of directing-group-free indolines (C5) and tetrahydroquinolines (C6) by Pd/S,O-ligand catalysis. In the presence of the S,O-ligand, a wide range of challenging indolines, tetrahydroquinolines, and olefins was efficiently olefinated under mild reaction conditions. The synthetic potential of this methodology was demonstrated by the efficient olefination of several indoline-based natural products.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902280 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.9b03505 | DOI Listing |
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